Sheng Wenbo, Li Wei, Li Bin, Li Cuihua, Xu Yisheng, Guo Xuhong, Zhou Feng, Jia Xin
School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region, Engineering Research Center of Materials-Oriented Chemical, Engineering of Xinjiang Bintuan Shihezi University, Shihezi, 832003, China.
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
Macromol Rapid Commun. 2015 Sep;36(18):1640-5. doi: 10.1002/marc.201500239. Epub 2015 Jul 14.
A thermo-controlled pesticide release system composed of poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) thin film grafted polydopamine (PDA) (PDMAEMA-g-PDA) microcapsules is reported. SiO2 microparticles are used as a template to prepare PDA-coated SiO2 microparticles. The thermally-responsive PDMAEMA thin films are grafted on PDA surfaces using a metal-free surface-initiated photopolymerization approach without adding any photo-initiator or photosensitizer under UV light irradiation. The subsequent acid etching yields PDMAEMA-g-PDA hollow microcapsules. PDMAEMA-g-PDA microcapsules exhibit well-controlled release of avermectin (Av). The results show that the loading ability of PDMAEMA-g-PDA microcapsules of Av is up to 52.7% (w/w). The release kinetics of Av demonstrate that Av@PDMAEMA-g-PDA microcapsules exhibit temperature-controlled release performance. This work is significant for controlled release systems. This simple design is expected to be used in various applications, such as in controlled drug release and agriculture-related fields.
报道了一种由接枝聚多巴胺（PDA）的聚（甲基丙烯酸2-（二甲氨基）乙酯）（PDMAEMA）薄膜组成的温控农药释放系统。二氧化硅（SiO₂）微粒用作模板来制备包覆PDA的SiO₂微粒。在紫外光照射下，采用无金属表面引发光聚合方法，在不添加任何光引发剂或光敏剂的情况下，将热响应性PDMAEMA薄膜接枝到PDA表面。随后的酸蚀刻得到PDMAEMA-g-PDA中空微胶囊。PDMAEMA-g-PDA微胶囊表现出对阿维菌素（Av）的良好控释性能。结果表明，PDMAEMA-g-PDA微胶囊对Av的负载能力高达52.7%（w/w）。Av的释放动力学表明，Av@PDMAEMA-g-PDA微胶囊具有温度控制的释放性能。这项工作对控释系统具有重要意义。这种简单的设计有望用于各种应用，如控释药物和农业相关领域。
