Nakamura Shin-Ichi, Hayashidani Hideki, Yonezawa Aya, Suzuki Isao, Une Yumi
Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Chuo-ku, Sagamihara, Kanagawa, Japan (Nakamura, Une)Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan (Hayashidani)Himeji Central Park, Himeji, Hyogo, Japan (Yonezawa, Suzuki).
Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Chuo-ku, Sagamihara, Kanagawa, Japan (Nakamura, Une)Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan (Hayashidani)Himeji Central Park, Himeji, Hyogo, Japan (Yonezawa, Suzuki)
J Vet Diagn Invest. 2015 Sep;27(5):641-4. doi: 10.1177/1040638715596035. Epub 2015 Jul 15.
Two meerkats (Suricata suricatta) housed in the same zoological garden in Japan died due to Yersinia pseudotuberculosis serotype 4b infection. Gross and microscopic lesions included necrotizing enteritis and enlargement of the spleen and liver with multifocal necrosis. Inflammatory cells, primarily neutrophils, and nuclear debris were associated with clusters of Gram-negative bacilli. Additionally, there were aberrant organism forms that were larger than bacilli and appeared as basophilic globular bodies. Immunohistochemical examination showed that the bacilli and globular bodies were strongly positive for Y. pseudotuberculosis O4 antigen. The globular bodies were considered a shape-changed form of Y. pseudotuberculosis, and these morphologically abnormal bacteria could present a diagnostic challenge.
日本同一动物园饲养的两只狐獴（南非狐獴）因感染4b型假结核耶尔森菌死亡。大体和显微镜下病变包括坏死性肠炎以及脾脏和肝脏肿大并伴有多灶性坏死。炎症细胞（主要是中性粒细胞）和核碎片与革兰氏阴性杆菌簇有关。此外，还有比杆菌更大的异常菌体形态，呈嗜碱性球形体。免疫组织化学检查显示，杆菌和球形体对假结核耶尔森菌O4抗原呈强阳性。球形体被认为是假结核耶尔森菌的形态改变形式，这些形态异常的细菌可能带来诊断挑战。
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