Riede Lara Luisa, Knauf-Witzens Tobias, Westerhüs Uta, Bonke Rebecca, Schlez Karen, Büttner Kathrin, Rau Jörg, Fischer Dominik, Grund Lisa, Roller Marco, Frei Andreas, Hertwig Stefan, Hammerl Jens Andre, Jäckel Claudia, Osmann Christine, Peters Martin, Sting Reinhard, Eisenberg Tobias
Zoological-Botanical Garden Wilhelma, 70376 Stuttgart, Germany.
Opel Hessian Zoo Foundation, 61476 Kronberg/Taunus, Germany.
Microorganisms. 2025 Feb 26;13(3):516. doi: 10.3390/microorganisms13030516.
Infections with the zoonotic pathogen (.) are commonly causing clinical diseases and acute deaths in various mammal and bird species in zoos. These findings prompted us to conduct a targeted study that included animals of 18 German and 1 Swiss zoo that had been affected by the pathogen previously. This study provides a comprehensive overview of susceptible zoo animal species, clinical signs, therapies, antimicrobial resistance, pathogen monitoring, and prophylactic measures. In addition, fecal samples from species with documented infections and organ samples from deceased mammals and birds from two of the participating zoos, the urban zoo Wilhelma and the rural Opel Zoo, were examined for using both direct plating and enrichment. The overall prevalence of was 3.1% at the Opel Zoo and 1.3% at the Wilhelma. Fecal samples yielded positive results in 1.4% of the tested samples from the Opel Zoo but none from the Wilhelma. Among carcasses, 16.7% and 1.7% tested positive at the Opel Zoo and the Wilhelma, respectively ( = 0.006). was significantly more frequently isolated during the cold season ( = 0.002). Affected animals often died suddenly, displaying no or only non-specific clinical signs, but postmortem examinations revealed septicemia with multiple bacterial organ abscesses. Rodents, ruminants, primates, and Piciformes were the most commonly affected orders. Considering the zoonotic potential of , this research underscores the importance of investigations in zoos in accordance with the targets of the One Health approach.
感染人畜共患病原体（.）通常会在动物园的各种哺乳动物和鸟类物种中引发临床疾病和急性死亡。这些发现促使我们开展一项针对性研究，研究对象包括此前曾受该病原体影响的18家德国动物园和1家瑞士动物园的动物。这项研究全面概述了易感的动物园动物物种、临床症状、治疗方法、抗菌药物耐药性、病原体监测和预防措施。此外，还对来自两家参与研究的动物园（城市动物园威廉玛动物园和乡村欧宝动物园）的有感染记录物种的粪便样本以及死亡哺乳动物和鸟类的器官样本进行了检测，采用直接接种和富集培养两种方法检测（.）。在欧宝动物园，（.）的总体患病率为3.1%，在威廉玛动物园为1.3%。欧宝动物园1.4%的检测粪便样本呈阳性结果，而威廉玛动物园则无阳性样本。在尸体样本中，欧宝动物园和威廉玛动物园的阳性率分别为16.7%和1.7%（P = 0.006）。在寒冷季节，（.）的分离频率显著更高（P = 0.002）。受感染动物常常突然死亡，未表现出或仅表现出非特异性临床症状，但尸检显示败血症伴有多个细菌性器官脓肿。啮齿动物、反刍动物、灵长类动物和雀形目是最常受影响的目。考虑到（.）的人畜共患病潜力，这项研究强调了按照“同一健康”方法的目标在动物园开展调查的重要性。
