Hu Dan-Ning, Mou Chih-Hsin, Chao Shih-Chun, Lin Ching-Yang, Nien Chan-Wei, Kuan Pei-Tzu, Jonas Jost B, Sung Fung-Chang
Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America; Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.
Institue of Clinical and Medical Science, China Medical University, Taichung, Taiwan; Management Office for Health Data, China Medical University and Hospital, Taichung, Taiwan.
PLoS One. 2015 Jul 16;10(7):e0132762. doi: 10.1371/journal.pone.0132762. eCollection 2015.
To determine the nationwide incidence of non-traumatic subconjunctival hemorrhage (NTSCH) in Taiwan from 2000-2011 and to analyze the risk factors for NTSCH using a case-control analysis.
This is a population-based cohort administrative database study. Randomly selected 1,000,000 residents from the Taiwan National Health Insurance Research Database in 2000 and followed for 12 years to determine the population incidence of NTSCH. Individuals with the first diagnosis of subconjunctival hemorrhage were identified by the corresponding International Classification of Diseases code (ICD) 372.72. Traumatic subconjunctival hemorrhages (ICD-9 codes 921, 871, 850-854 and 959.01) were excluded. The association of NTSCH with various demographic factors, comorbidities and use of medications was studied by a population based case-control analysis using data of 2008-2011.
A total of 67,720 patients with a first-time diagnosis of NTSCH were identified during the 12 years period. The mean annual incidence was 65 per 10,000 individuals (crude incidence) and 60 per 10,000 individuals (age- and sex-standardized incidence). The incidence rate of NTSCH was higher in women than in men, [men-women ratio: 0.80 (95% confidence interval: 0.78-0.81)]. The age-specific incidence decreased from childhood to the group of teenagers, after which it increased to a maximal value of 136.2 per 10,000 people in the age group of 60-69 years. Case-control analysis showed that comorbidities of hypertension, purpura and thrombocytopenia, and the use of aspirin were significantly associated with the risk of NTSCH.
This study indicates that NTSCH is a common eye disease that occurs once in 167 individuals in a general East Asian population per year. It occurs more often in women than in men and the age-specific incidence peaked in the age group of 60-69 years. Hypertension, purpura and thrombocytopenia, and the use of aspirin are the major risk factors for NTSCH.
确定2000 - 2011年台湾地区非创伤性结膜下出血（NTSCH）的全国发病率，并通过病例对照分析来分析NTSCH的危险因素。
这是一项基于人群队列的行政数据库研究。2000年从台湾国民健康保险研究数据库中随机选取100万居民，并随访12年以确定NTSCH的人群发病率。通过相应的国际疾病分类代码（ICD）372.72识别首次诊断为结膜下出血的个体。排除创伤性结膜下出血（ICD - 9代码921、871、850 - 854和959.01）。利用2008 - 2011年的数据，通过基于人群的病例对照分析研究NTSCH与各种人口统计学因素、合并症及药物使用之间的关联。
在12年期间共识别出67720例首次诊断为NTSCH的患者。年平均发病率为每10000人65例（粗发病率）和每10000人60例（年龄和性别标准化发病率）。NTSCH的发病率女性高于男性，[男女比例：0.80（95%置信区间：0.78 - 0.81）]。特定年龄发病率从儿童期到青少年组下降，之后在60 - 69岁年龄组升至最高值，每10000人中有136.2例。病例对照分析表明，高血压、紫癜和血小板减少症合并症以及阿司匹林的使用与NTSCH风险显著相关。
本研究表明，NTSCH是一种常见眼病，在一般东亚人群中每年每167人中有1人发病。女性比男性更常发病，特定年龄发病率在60 - 69岁年龄组达到峰值。高血压、紫癜和血小板减少症以及阿司匹林的使用是NTSCH的主要危险因素。
