Department of Ophthalmology, Taipei Medical University Hospital, Taipei, Taiwan.
Acta Ophthalmol. 2013 May;91(3):226-30. doi: 10.1111/j.1755-3768.2011.02359.x. Epub 2012 Mar 9.
To the best of our knowledge, no large population-based studies on the relationship between conjunctival haemorrhage and stroke have been conducted to date. Using a nationwide population-based data set, this study investigated the relationship between conjunctival haemorrhage and the subsequent risk of stroke within a 3-year period following diagnosis.
We analysed data sourced from the Taiwan Longitudinal Health Insurance Database 2000. The study cohort consisted of 17 349 patients with conjunctival haemorrhage and 86 745 comparison subjects. Each patient was individually tracked for a 3-year period from their index date to identify all those who had subsequently received a diagnosis of stroke.
The incidence rate of stroke was 2.44 (95% CI = 2.31-2.55) per 100 person-years in patients with conjunctival haemorrhage and 1.63 (95% CI = 1.59-1.68) per 100 person-years in comparison patients. After adjusting for patients' monthly income and geographic location, as well as for hypertension, atrial fibrillation, diabetes, hyperlipidaemia and coronary heart disease, stratified Cox proportional hazards regressions revealed a statistically significant hazard ratio for stroke in patients with conjunctival haemorrhage (HR = 1.33; 95% CI = 1.24-1.42, p < 0.001).
In this study, patients with conjunctival haemorrhage were found to be at a significant risk of stroke during a 3-year follow-up period after diagnosis.
据我们所知，目前尚未有针对结膜下出血与中风之间关系的大型基于人群的研究。本研究利用全国性基于人群的数据集，调查了在诊断后 3 年内结膜下出血与随后中风风险之间的关系。
我们分析了源自台湾健保资料库 2000 年的数据。研究队列由 17349 例结膜下出血患者和 86745 例对照患者组成。每位患者从其指数日期开始单独跟踪 3 年，以确定所有随后被诊断为中风的患者。
结膜下出血患者中风的发生率为 2.44（95%可信区间=2.31-2.55）/100 人年，而对照患者为 1.63（95%可信区间=1.59-1.68）/100 人年。在校正了患者的月收入和地理位置以及高血压、心房颤动、糖尿病、高脂血症和冠心病后，分层 Cox 比例风险回归显示结膜下出血患者中风的风险比具有统计学意义（HR=1.33；95%可信区间=1.24-1.42，p<0.001）。
在这项研究中，诊断后 3 年的随访期间，结膜下出血患者发生中风的风险显著增加。
