述评：白细胞介素-4和白细胞介素-13受体与信号传导
Commentary: IL-4 and IL-13 receptors and signaling.
作者信息
McCormick Sarah M, Heller Nicola M
机构信息
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
出版信息
Cytokine. 2015 Sep;75(1):38-50. doi: 10.1016/j.cyto.2015.05.023. Epub 2015 Jul 14.
Abstract
Interleukin (IL)-4 and IL-13 were discovered approximately 30years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.
摘要
白细胞介素（IL）-4和IL-13大约在30年前被发现，随即被认为与过敏和特应性疾病有关。从那时起，IL-4和IL-13及其受体在正常妊娠、胎儿发育、神经功能以及癌症和纤维化发病机制中的新作用逐渐被认识。对IL-4/-13及其受体的研究揭示了细胞因子生物学的重要线索，并促成了众多实验性治疗方法的开发。本文旨在突出新发现，并整合IL-4和IL-13在结构、受体调节、信号传导及实验性治疗领域的相关概念。
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