Doadrio Antonio L, Conde A, Arenas M A, Hernández-López J M, de Damborenea J J, Pérez-Jorge Concepción, Esteban Jaime, Vallet-Regí Maria
Departamento de Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain.
Departamento de Ingeniería de superficies Corrosión y Durabilidad, Centro Nacional de Investigaciones Metalúrgicas, CENIM-CSIC, Avda. Gregorio del Amo, 8, 28040 Madrid, Spain.
Int J Pharm. 2015 Aug 15;492(1-2):207-12. doi: 10.1016/j.ijpharm.2015.07.046. Epub 2015 Jul 19.
The use of osteoarticular implants has improved the quality of life of millions of patients. In this work nanotubular structures tailored made on Ti6Al4V substrates was used as drug delivery system of ibuprofen as a proof of concept. Three different nanotubular films with different sizes and forms (NT, NT+ and NTb) were analysed. Samples were soaked in a solution of 660 mg ibuprofen/20 mL n-pentane. The ibuprofen release in aqueous medium was evaluated by liquid chromatography reversed-phase (RP-HPLC). To calculate the observed constant k, the amount of ibuprofen released was plotted versus the time using linear regression according to the zero-order, first-order, second-order and Higuchi model. The release of ibuprofen was constant and independent of the concentration. The kinetic constant obtained was 0.021 (NT), 0.022 (NT+) and 0.013 (NTb) being the correlation factor of 0.98 (zero-order) where the maximum correlation factor was reached. These results indicate that the delivery process from NT and NT+ is similar and slower that NTb. In all the cases was inside the therapeutically range. These results showed the potential of these modifications in order to develop implants that can carry different molecules of medical importance.
骨关节植入物的使用改善了数百万患者的生活质量。在这项工作中，在Ti6Al4V基底上定制的纳米管结构被用作布洛芬的药物递送系统，作为概念验证。分析了三种具有不同尺寸和形态的不同纳米管薄膜（NT、NT+和NTb）。将样品浸泡在660 mg布洛芬/20 mL正戊烷的溶液中。通过反相液相色谱法（RP-HPLC）评估布洛芬在水性介质中的释放。为了计算观察到的常数k，根据零级、一级、二级和Higuchi模型，使用线性回归将布洛芬释放量与时间作图。布洛芬的释放是恒定的，且与浓度无关。获得的动力学常数分别为0.021（NT）、0.022（NT+）和0.013（NTb），相关系数为0.98（零级），达到了最大相关系数。这些结果表明，NT和NT+的递送过程相似，且比NTb慢。在所有情况下，均在治疗范围内。这些结果显示了这些修饰在开发能够携带不同具有医学重要性分子的植入物方面的潜力。
