脑钠肽对大鼠脱水或血管紧张素II诱导的饮水的影响。

Effect of brain natriuretic peptide on dehydration- or angiotensin II-induced water intake in rats.

作者信息

Fregoneze J B, Gutkowska J, St-Pierre S, Antunes-Rodrigues J

机构信息

Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.

出版信息

Braz J Med Biol Res. 1989;22(6):765-8.

PMID:2620189

Abstract

The present study was performed to evaluate the effect of 3rdV injection on water intake of brain natriuretic peptide (BNP), which is structurally different from the atrial natriuretic peptide. BNP was recently isolated from porcine brain and appears to have a different precursor than the family of atrial natriuretic peptides. Central administration of BNP 3rdV decreased water intake. At a dose of 2.0 nmol/rat, BNP partially inhibited dehydration-induced water intake and completely blocked the stimulatory effect of 478 pmol/rat angiotensin II in rats.

摘要

本研究旨在评估第三脑室注射对脑钠肽（BNP）水摄入量的影响，BNP在结构上与心房钠尿肽不同。BNP最近从猪脑中分离出来，其前体似乎与心房钠尿肽家族不同。第三脑室注射BNP可减少水摄入量。在剂量为2.0 nmol/大鼠时，BNP部分抑制脱水诱导的水摄入，并完全阻断大鼠中478 pmol/大鼠血管紧张素II的刺激作用。