脑室内注射脑钠肽可抑制清醒大鼠的血管加压素分泌。
Intracerebroventricular injection of brain natriuretic peptide inhibits vasopressin secretion in conscious rats.
作者信息
Yamada T, Nakao K, Itoh H, Shirakami G, Kangawa K, Minamino N, Matsuo H, Imura H
机构信息
Department of Medicine, Kyoto University School of Medicine, Japan.
出版信息
Neurosci Lett. 1988 Dec 19;95(1-3):223-8. doi: 10.1016/0304-3940(88)90661-1.
The effect of intracerebroventricular (i.c.v.) injection of brain natriuretic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of BNP (0.01, 0.1 or 1 nmol) significantly inhibited basal AVP secretion and the effect of BNP was comparable to that of ANP. The AVP secretion induced by i.c.v. injection of angiotensin II (0.1 nmol) was significantly suppressed by the pretreatment with BNP (0.1 or 1 nmol). These results suggest that BNP is involved in the central control of AVP secretion either alone or in combination with brain ANP.
在清醒、自由活动的大鼠中研究了脑室内（i.c.v.）注射从猪脑中纯化的新型肽脑钠肽（BNP）对精氨酸加压素（AVP）分泌的影响，并与心钠素（ANP）的影响进行了比较。脑室内注射BNP（0.01、0.1或1 nmol）可显著抑制基础AVP分泌，且BNP的作用与ANP相当。脑室内注射血管紧张素II（0.1 nmol）诱导的AVP分泌可被BNP（0.1或1 nmol）预处理显著抑制。这些结果表明，BNP单独或与脑ANP联合参与AVP分泌的中枢控制。
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