University of Edinburgh, Edinburgh, UK.
Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK.
Intensive Care Med. 2015 Oct;41(10):1809-16. doi: 10.1007/s00134-015-3980-1. Epub 2015 Jul 23.
Evidence of variation in mortality after surgery may indicate preventable postoperative death. We sought to determine if regional differences in outcome were present in surgical patients admitted to critical care in the UK.
We extracted data on admission characteristics, case mix and outcome of all patients admitted to UK critical care units following surgery for the calendar year of 2009. We also used publicly held data on regional population, volume of surgery and bed provision. Multilevel regression analysis was used to adjust for the effects of case mix and regional critical care bed provision on acute hospital mortality.
A total of 16,147 patients admitted to critical care following surgery were included in this analysis. Median odds ratio (MOR) was used to describe regional-level variance in acute hospital mortality. Significant variation was identified (MOR 1.14; 95% CI 1.07, 1.28) and persisted following adjustment for case mix (MOR 1.10; 95% CI 1.04, 1.25) and regional critical care bed provision (MOR 1.09; 95% CI 1.04, 1.24). Critical care bed utilisation (surgical critical care admissions per 100,000 surgical procedures) seemed to better explain this observation (MOR 1.03; 95% CI 1.00, 29.26) and was associated with statistically significant reduction in mortality (OR 0.91; 95% CI 0.85, 0.97; p = 0.01).
Significant regional variation in hospital mortality for patients admitted to critical care following surgery was observed. Critical care bed utilisation seemed to better explain this observation and was associated with improved outcome.
手术后死亡率的变化可能表明存在可预防的术后死亡。我们旨在确定在英国接受重症监护的外科患者是否存在结果的区域差异。
我们提取了 2009 年所有接受外科手术后入住英国重症监护病房的患者的入院特征、病例组合和结局数据。我们还使用了公开的区域人口、手术量和床位配置数据。使用多水平回归分析调整病例组合和区域重症监护床位配置对急性医院死亡率的影响。
共纳入 16147 例接受外科手术后入住重症监护病房的患者。中位数优势比(MOR)用于描述急性医院死亡率的区域水平差异。确定存在显著差异(MOR 1.14;95%CI 1.07,1.28),并在调整病例组合(MOR 1.10;95%CI 1.04,1.25)和区域重症监护床位配置(MOR 1.09;95%CI 1.04,1.24)后仍然存在。重症监护床位使用率(每 10 万例手术的外科重症监护入院人数)似乎更好地解释了这一观察结果(MOR 1.03;95%CI 1.00,29.26),并与死亡率的统计学显著降低相关(OR 0.91;95%CI 0.85,0.97;p=0.01)。
观察到手术后入住重症监护病房的患者的医院死亡率存在显著的区域差异。重症监护床位使用率似乎更好地解释了这一观察结果,并与改善结局相关。