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微小RNA在人类嗜T淋巴细胞病毒1型感染及成人T细胞白血病发病机制中的新作用

The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis.

作者信息

Moles Ramona, Nicot Christophe

机构信息

Department of Pathology and Laboratory Medicine, Center for Viral Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

出版信息

Viruses. 2015 Jul 20;7(7):4047-74. doi: 10.3390/v7072805.

DOI:10.3390/v7072805
PMID:26205403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4517134/
Abstract

Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. In recent years, cellular as well as virus-encoded microRNA (miRNA) have been shown to deregulate signaling pathways to favor virus life cycle. HTLV-1 does not encode miRNA, but several studies have demonstrated that cellular miRNA expression is affected in infected cells. Distinct mechanisms such as transcriptional, epigenetic or interference with miRNA processing machinery have been involved. This article reviews the current knowledge of the role of cellular microRNAs in virus infection, replication, immune escape and pathogenesis of HTLV-1.

摘要

人类T细胞白血病病毒1型（HTLV-1）是一种人类逆转录病毒，也是成人T细胞白血病/淋巴瘤（ATLL）的病原体，ATLL是一种CD4/CD25+T淋巴细胞的致命恶性肿瘤。近年来，细胞来源的以及病毒编码的微小RNA（miRNA）已被证明可使信号通路失调，从而有利于病毒生命周期。HTLV-1不编码miRNA，但多项研究表明，受感染细胞中的细胞miRNA表达会受到影响。其中涉及转录、表观遗传或对miRNA加工机制的干扰等不同机制。本文综述了目前关于细胞微小RNA在HTLV-1病毒感染、复制、免疫逃逸和发病机制中作用的相关知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/67089211422d/viruses-07-02805-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/262699e0c35d/viruses-07-02805-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/f7c873eeff23/viruses-07-02805-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/fd44c6e58f6e/viruses-07-02805-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/e3f454513f97/viruses-07-02805-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/dbaaddadbaca/viruses-07-02805-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/67089211422d/viruses-07-02805-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/262699e0c35d/viruses-07-02805-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/f7c873eeff23/viruses-07-02805-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/fd44c6e58f6e/viruses-07-02805-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/e3f454513f97/viruses-07-02805-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/dbaaddadbaca/viruses-07-02805-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a2/4517134/67089211422d/viruses-07-02805-g006.jpg

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Neoplasia. 2015 May;17(5):449-62. doi: 10.1016/j.neo.2015.04.005.
2
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BMC Cancer. 2015 Jan 31;15:29. doi: 10.1186/s12885-015-1031-5.
3
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5
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