精神分裂症中的皮质折叠及预后神经影像学潜力

Cortical folding and the potential for prognostic neuroimaging in schizophrenia.

作者信息

Guo Shuixia, Iwabuchi Sarina, Balain Vijender, Feng Jianfeng, Liddle Peter, Palaniyappan Lena

机构信息

Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada.

Shuixia Guo, PhD, College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Sarina Iwabuchi, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Vijender Balain, MRCPsych, Penticton Regional Hospital, Penticton, British Columbia, Canada; Jianfeng Feng, PhD, Shanghai Center for Mathematical Sciences, Fudan University, Shanghai, PR China and Department of Computer Science, University of Warwick, Coventry, UK; Peter Liddle, PhD, Division of Psychiatry & Applied Psychology, University of Nottingham and Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK; Lena Palaniyappan, PhD, MRCPsych, Division of Psychiatry & Applied Psychology, University of Nottingham, Centre for Translational Neuroimaging, Institute of Mental Health, Nottingham, UK and Penticton Regional Hospital, Penticton, British Columbia, Canada

出版信息

Br J Psychiatry. 2015 Nov;207(5):458-9. doi: 10.1192/bjp.bp.114.155796. Epub 2015 Jul 23.

DOI:10.1192/bjp.bp.114.155796
PMID:26206860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4629075/
Abstract

In 41 patients with schizophrenia, we used neuroanatomical information derived from structural imaging to identify patients with more severe illness, characterised by high symptom burden, low processing speed, high degree of illness persistence and lower social and occupational functional capacity. Cortical folding, but not thickness or volume, showed a high discriminatory ability in correctly identifying patients with more severe illness.

摘要

在41例精神分裂症患者中，我们利用结构成像得出的神经解剖学信息来识别病情更严重的患者，其特征为症状负担重、处理速度慢、疾病持续时间长以及社会和职业功能能力较低。皮质折叠而非厚度或体积在正确识别病情更严重的患者方面具有较高的辨别能力。

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