Rillaerts E G, Engelmann G J, Van Camp K M, De Leeuw I
Laboratory for Endocrinology and Nutrition, University of Antwerp, Wilrijk, Belgium.
Diabetes. 1989 Nov;38(11):1412-6. doi: 10.2337/diab.38.11.1412.
Twelve type I (insulin-dependent) diabetic subjects in stable metabolic control for at least 3 mo received a controlled diet containing 50% carbohydrate, 35% fat, and 15% protein. Calorie intake varied from 1800 to 2200 calories, depending on individual needs. Part of the polyunsaturated omega-6 fatty acids (omega 6FAs) were isocalorically exchanged with omega 3FAs (2.7 g/day provided by fish oil concentrates) for 10 wk. Subject selection was based on the fact that the atherogenic index (total cholesterol/high-density lipoprotein cholesterol [HDL-chol]) remained greater than 5. Total cholesterol did not change, but HDL-chol (P less than .05) increased significantly, and the mean +/- SD atherogenic index decreased from 5.9 +/- 1.1 to 5.1 +/- 1.3. Plasma triglyceride levels also decreased (P less than .05). There was a small (approximately 2%) but significant (P less than .05) decrease of whole-blood viscosity at low shear rate because of a similarly small (approximately 2% decrease (P less than .05) of plasma viscosity. Erythrocyte viscosity values and the erythrocyte transit time, measured with the St. George's filtrometer, remained unchanged during fish oil intake. Four weeks after stopping the omega 3FA administration, the triglyceride level was again increased (P less than .05) and was even higher than the starting value (P less than .05). Plasma and whole-blood viscosity also increased to the starting levels, demonstrating that lipid alterations are accompanied with blood viscosity changes in the presence of a stable metabolic control.
12名代谢稳定控制至少3个月的I型（胰岛素依赖型）糖尿病患者接受了一种控制饮食，其中碳水化合物占50%，脂肪占35%，蛋白质占15%。热量摄入根据个体需求在1800至2200卡路里之间变化。部分多不饱和ω-6脂肪酸（ω-6FAs）与ω-3FAs进行等热量交换（由鱼油浓缩物提供2.7克/天），持续10周。受试者选择基于动脉粥样硬化指数（总胆固醇/高密度脂蛋白胆固醇[HDL-chol]）仍大于5这一事实。总胆固醇没有变化，但HDL-chol（P<0.05）显著增加，平均±标准差动脉粥样硬化指数从5.9±1.1降至5.1±1.3。血浆甘油三酯水平也下降了（P<0.05）。由于血浆粘度有类似的小幅下降（约2%，P<0.05），低剪切率下全血粘度有小幅（约2%）但显著的下降（P<0.05）。在用圣乔治滤过仪测量时，红细胞粘度值和红细胞通过时间在摄入鱼油期间保持不变。停止给予ω-3FA四周后，甘油三酯水平再次升高（P<0.05），甚至高于起始值（P<0.05）。血浆和全血粘度也增加到起始水平，表明在稳定的代谢控制下，脂质改变伴随着血液粘度变化。
