Tarita-Nistor Luminita, Eizenman Moshe, Landon-Brace Natalie, Markowitz Samuel N, Steinbach Martin J, González Esther G
*PhD †MD Vision Science Research Program, Toronto Western Hospital, Toronto, Ontario, Canada (LT-N, ME, MJS, EGG); and Department of Biomedical Engineering (ME), Department of Ophthalmology and Vision Sciences (ME, SNM, MJS, EGG), and Division of Engineering Science (NL-B), University of Toronto, Toronto, Ontario, Canada.
Optom Vis Sci. 2015 Aug;92(8):863-72. doi: 10.1097/OPX.0000000000000641.
We present a new method for identifying the absolute location (i.e., relative to the optic disc) of the preferred retinal location (PRL) simultaneously for the two eyes of patients with central vision loss. For this, we used a binocular eye-tracking system that determines the pupillary axes of both eyes without a user calibration routine.
During monocular viewing, we measured the pupillary axis and the angle between it and the visual axis (angle Kappa) for 10 eyes with normal vision. We also determined their fovea location relative to the middle of the optic disc with the MP-1 microperimeter. Then, we created a transformation between the eye-tracking and microperimeter measurements. We used this transformation to predict the absolute location of the monocular and binocular PRLs of nine patients with central vision loss. The accuracy of the monocular prediction was evaluated with the microperimeter. The binocular PRLs were checked for retinal correspondence and functionality by placing them on fundus photographs.
The transformation yielded an average error for the monocular measures of 0.2 (95% confidence interval, 1.0 to -0.6 degrees) horizontally and 0.5 (95% confidence interval, 1.1 to -0.1 degrees) vertically. The predicted binocular measures showed that the PRLs were generally in corresponding locations in the two eyes. One patient whose PRLs were not in corresponding positions complained about diplopia. For all patients, at least one PRL fell onto functional retina during binocular viewing.
This study shows that measurements of the location of the binocular PRLs relative to the pupillary axes can be transformed into absolute locations.
我们提出了一种新方法,用于同时确定中心视力丧失患者双眼的首选视网膜位置(PRL)的绝对位置(即相对于视盘)。为此,我们使用了一种双目眼动追踪系统,该系统无需用户校准程序即可确定双眼的瞳孔轴。
在单眼观察期间,我们测量了10只视力正常眼睛的瞳孔轴及其与视轴之间的角度(kappa角)。我们还使用MP-1微型视野计确定了它们的中央凹相对于视盘中心的位置。然后,我们在眼动追踪测量和微型视野计测量之间建立了一种转换关系。我们使用这种转换关系来预测9例中心视力丧失患者单眼和双眼PRL的绝对位置。用微型视野计评估单眼预测的准确性。通过将双眼PRL放置在眼底照片上来检查视网膜对应性和功能性。
该转换关系得出的单眼测量平均误差在水平方向为0.2(95%置信区间,1.0至-0.6度),在垂直方向为0.5(95%置信区间,1.1至-0.1度)。预测的双眼测量结果表明,PRL通常在双眼的相应位置。一名PRL不在相应位置的患者抱怨有复视。对于所有患者,在双眼观察期间,至少有一个PRL落在功能性视网膜上。
本研究表明,相对于瞳孔轴的双眼PRL位置测量可以转换为绝对位置。