Bottoni Ugo, Tiriolo Raffaele, Pullano Salvatore A, Dastoli Stefano, Amoruso Giuseppe F, Nisticò Steven P, Fiorillo Antonino S
IEEE Trans Biomed Eng. 2016 Feb;63(2):379-84. doi: 10.1109/TBME.2015.2458967. Epub 2015 Jul 21.
Psoriasis is a chronic skin disease which is very common in the population and requires frequent clinical and pharmacological treatment. In the following, a study based on Fourier transform infrared spectroscopy analyzing saliva proteomic components in psoriatic patients against diabetic patients and a control group is presented. Clinical analysis showed a prominent amide II band, at around 1545 cm(-1), and the composition of the amide I band, at around 1647 cm(-1), allowing us to distinguish the infrared salivary signature of psoriatic and diabetic patients from the control group and even from patients with different kinds of psoriasis. Moreover, results highlighted existing differences in the secondary structure composition of proteins between psoriatic and diabetic patients as compared to the control group. In fact, the saliva spectra of the control group and that of the palmoplantar psoriatic patients differ from plaque psoriasis and diabetic patient spectra because of the absence of the amide II band and the presence of different secondary protein-structure conformations.
银屑病是一种慢性皮肤病，在人群中非常常见，需要频繁进行临床和药物治疗。以下是一项基于傅里叶变换红外光谱的研究，该研究分析了银屑病患者与糖尿病患者以及对照组的唾液蛋白质组成分。临床分析显示，在约1545 cm(-1)处有一个突出的酰胺II带，以及在约1647 cm(-1)处的酰胺I带的组成，这使我们能够将银屑病患者和糖尿病患者的红外唾液特征与对照组区分开来，甚至与不同类型银屑病的患者区分开来。此外，结果突出了银屑病患者和糖尿病患者与对照组相比，蛋白质二级结构组成存在差异。事实上，对照组和掌跖部银屑病患者的唾液光谱与斑块状银屑病和糖尿病患者的光谱不同，这是因为缺乏酰胺II带以及存在不同的蛋白质二级结构构象。
