Patterson R, Harris K E, Suszko I M
Am Rev Respir Dis. 1977 Jun;115(6):929-36. doi: 10.1164/arrd.1977.115.6.929.
Immunologic stimuli to the airway of rhesus monkeys were given by aerosol challenge with ascaris antigen or anti-IgE. Both of these stimuli produce immediate-type airway responses. When 2 sequential aerosol challenges were given during the same experiment, the response following the second stimulus was always less than or equal to the first response following any combination of stimuli except the anti-IgE-ascaris sequence. The second response following the latter challenge was always greater than or equal to the first response. The possibility that this exception was the result of anti-IgE priming mediator releasing cells for antigen was not supported by in vitro experiments. It is suggested that the results obtained with the anti-IgE-ascaris sequence may relate to the presence of intralumenal mast cells in the bronchi and the molecular weights of the 2 immunologic stimuli.
通过用蛔虫抗原或抗IgE进行雾化激发，对恒河猴气道给予免疫刺激。这两种刺激都会产生速发型气道反应。在同一实验中当给予两次连续的雾化激发时，除了抗IgE-蛔虫序列外，在任何刺激组合后，第二次刺激后的反应总是小于或等于第一次反应。后一种激发后的第二次反应总是大于或等于第一次反应。体外实验不支持这种例外情况是抗IgE使介质释放细胞对抗原产生致敏作用的结果这一可能性。提示用抗IgE-蛔虫序列获得的结果可能与支气管腔内肥大细胞的存在以及两种免疫刺激的分子量有关。
