Bennett Richard J
Department of Molecular Microbiology and Immunology, Brown University, 171 Meeting St, Providence, RI 02912, United States.
Curr Opin Microbiol. 2015 Dec;28:10-7. doi: 10.1016/j.mib.2015.06.017. Epub 2015 Jul 25.
Candida albicans is both a prevalent human commensal and the most commonly encountered human fungal pathogen. This lifestyle is dependent on the ability of the fungus to undergo rapid genetic and epigenetic changes, often in response to specific environmental cues. A parasexual cycle in C. albicans has been defined that includes several unique properties when compared to the related model yeast, Saccharomyces cerevisiae. Novel features include strict regulation of mating via a phenotypic switch, enhanced conjugation within a sexual biofilm, and a program of concerted chromosome loss in place of a conventional meiosis. It is expected that several of these adaptations co-evolved with the ability of C. albicans to colonize the mammalian host.
白色念珠菌既是一种常见的人体共生菌，也是最常遇到的人类真菌病原体。这种生存方式取决于真菌能够快速发生基因和表观遗传变化的能力，这种变化通常是对特定环境线索的响应。白色念珠菌中的准性生殖周期已被定义，与相关的模式酵母酿酒酵母相比，它具有几个独特的特性。新特性包括通过表型转换严格调控交配、在有性生物膜内增强接合，以及一系列协调的染色体丢失程序以取代传统的减数分裂。预计这些适应性变化中的几种与白色念珠菌在哺乳动物宿主体内定殖的能力共同进化。
