Memish Ziad A, Al-Tawfiq Jaffar A, Alhakeem Rafat F, Assiri Abdullah, Alharby Khalid D, Almahallawi Maher S, Alkhallawi Mohammed
Ministry of Health, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN, USA.
Travel Med Infect Dis. 2015 Jul-Aug;13(4):311-4. doi: 10.1016/j.tmaid.2015.06.012. Epub 2015 Jul 15.
Since the initial description of the Middle East respiratory syndrome (MERS) in September 2012, a total of 1038 cases of MERS-CoV including 460 deaths have been reported from Saudi Arabia. From August 24, 2013 to September 3, 2013, a total of 397 patients and contacts were tested for MERS-CoV. Of those tested, there were 18 (4.5%) MERS-CoV cases reported in Al-Madinah al-Munawwarah with one large cluster. In this report, we describe the outcome, epidemiology and clinical characteristics of this cluster of which 4 cases involved healthcare workers. Fourteen cases appeared to be linked to one cluster involving healthcare workers (HCWs), family and patient contacts. Of the 18 cases, five (including 2 HCWs) were community acquired, two were household contacts, and 11 were healthcare associated (including 4 HCWs). All except 4 cases were symptomatic and the case fatality rate was 39% (7 of 18). The outbreak resulted in human to human transmission of an estimated 6 cases. Contact screening showed positive test in 1 of 56 (1.8%) household contacts, and 3 of 250 (1.2%) HCWs.
自2012年9月首次描述中东呼吸综合征（MERS）以来，沙特阿拉伯共报告了1038例中东呼吸综合征冠状病毒（MERS-CoV）感染病例，其中460人死亡。2013年8月24日至2013年9月3日，共有397名患者及接触者接受了MERS-CoV检测。在接受检测的人中，麦地那有18例（4.5%）MERS-CoV感染病例报告，其中有一个大的聚集性病例群。在本报告中，我们描述了该聚集性病例群的结局、流行病学及临床特征，其中4例涉及医护人员。14例病例似乎与一个涉及医护人员、家属及患者接触者的聚集性病例群有关。在这18例病例中，5例（包括2名医护人员）为社区获得性感染，2例为家庭接触者感染，11例为医院相关感染（包括4名医护人员）。除4例病例外，其余均有症状，病死率为39%（18例中的7例）。此次疫情导致了约6例的人传人感染。接触者筛查显示，56名家庭接触者中有1例（1.8%）检测呈阳性，250名医护人员中有3例（1.2%）检测呈阳性。
