生物相容性D-青霉胺共轭金纳米颗粒：靶向细胞内游离铜离子进行解毒
Biocompatible D-Penicillamine Conjugated Au Nanoparticles: Targeting Intracellular Free Copper Ions for Detoxification.
作者信息
Kandanapitiye Murthi S, Gunathilake Chamila, Jaroniec Mietek, Huang Songping D
机构信息
Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA.
出版信息
J Mater Chem B. 2015 Jul 21;3(27):5553-5559. doi: 10.1039/C5TB00189G.
Abstract
High thiophillicicity of the Au-nanoparticle (Au NP) surface leads to covalent attachment of D-penicillamine molecules to Au NPs to form biocompatible D-penicillamine conjugated Au NPs. The latter are highly water-dispersible, exhibit no cytotoxicity, and can readily penetrate the cell membrane to target intracellular free copper ions for selective copper detoxification in the presence of the other divalent essential metal ions including Zn(II), Fe(II), Mn(II), Ca(II), and Mg(II), thus opening up a new avenue for improving the efficacy and pharmacokinetics of D-penicillamine, an important clinical drug currently used to treat the copper overload-related diseases and disorders.
摘要
金纳米颗粒（Au NP）表面的高亲硫性导致D-青霉胺分子与Au NPs共价连接，形成生物相容性的D-青霉胺共轭Au NPs。后者具有高度的水分散性，无细胞毒性，并且在包括Zn(II)、Fe(II)、Mn(II)、Ca(II)和Mg(II)在内的其他二价必需金属离子存在的情况下，能够轻易穿透细胞膜靶向细胞内游离铜离子以进行选择性铜解毒，从而为改善D-青霉胺（一种目前用于治疗与铜过载相关疾病和病症的重要临床药物）的疗效和药代动力学开辟了一条新途径。
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