Keadle Sarah K, Moore Steven C, Sampson Joshua N, Xiao Qian, Albanes Demetrius, Matthews Charles E
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland; Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland;.
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Am J Prev Med. 2015 Dec;49(6):811-21. doi: 10.1016/j.amepre.2015.05.023. Epub 2015 Jul 26.
TV viewing is the most prevalent sedentary behavior and is associated with increased risk of cardiovascular disease and cancer mortality, but the association with other leading causes of death is unknown. This study examined the association between TV viewing and leading causes of death in the U.S.
A prospective cohort of 221,426 individuals (57% male) aged 50-71 years who were free of chronic disease at baseline (1995-1996), 93% white, with an average BMI of 26.7 (SD=4.4) kg/m(2) were included. Participants self-reported TV viewing at baseline and were followed until death or December 31, 2011. Hazard ratios (HRs) and 95% CIs for TV viewing and cause-specific mortality were estimated using Cox proportional hazards regression. Analyses were conducted in 2014-2015.
After an average follow-up of 14.1 years, adjusted mortality risk for a 2-hour/day increase in TV viewing was significantly higher for the following causes of death (HR [95% CI]): cancer (1.07 [1.03, 1.11]); heart disease (1.23 [1.17, 1.29]); chronic obstructive pulmonary disease (1.28 [1.14, 1.43]); diabetes (1.56 [1.33, 1.83]); influenza/pneumonia (1.24 [1.02, 1.50]); Parkinson disease (1.35 [1.11, 1.65]); liver disease (1.33 [1.05, 1.67]); and suicide (1.43 [1.10, 1.85]. Mortality associations persisted in stratified analyses with important potential confounders, reducing causation concerns.
This study shows the breadth of mortality outcomes associated with prolonged TV viewing, and identifies novel associations for several leading causes of death. TV viewing is a prevalent discretionary behavior that may be a more important target for public health intervention than previously recognized.
ClinicalTrials.gov number, NCT00340015.
看电视是最普遍的久坐行为,与心血管疾病和癌症死亡率增加相关,但与其他主要死因的关联尚不清楚。本研究调查了美国看电视与主要死因之间的关联。
纳入了一个前瞻性队列,共221,426名年龄在50 - 71岁之间的个体(57%为男性),他们在基线时(1995 - 1996年)无慢性病,93%为白人,平均体重指数为26.7(标准差 = 4.4)kg/m²。参与者在基线时自我报告看电视的情况,并随访至死亡或2011年12月31日。使用Cox比例风险回归估计看电视与特定病因死亡率的风险比(HRs)和95%置信区间(CIs)。分析于2014 - 2015年进行。
平均随访14.1年后,每天看电视增加2小时,以下死因的调整后死亡风险显著更高(HR [95% CI]):癌症(1.07 [1.03, 1.11]);心脏病(1.23 [1.17, (此处原文可能有误,推测应为1.29)1.29]);慢性阻塞性肺疾病(1.28 [1.14, 1.43]);糖尿病(1.56 [1.33, 1.83]);流感/肺炎(1.24 [1.02, 1.50]);帕金森病(1.35 [1.11, 1.65]);肝病(1.33 [1.05, 1.67]);以及自杀(1.43 [1.10, 1.85])。在对重要潜在混杂因素进行分层分析时,死亡率关联仍然存在,减少了对因果关系的担忧。
本研究显示了长时间看电视与多种死亡结局相关,并确定了几种主要死因的新关联。看电视是一种普遍的自主行为,可能是比以前认识到的更重要的公共卫生干预目标。
ClinicalTrials.gov编号,NCT00340015。 (注:原文中“心脏病(1.23 [1.17, 1.29])”括号内第二个数字推测有误,可能应为1.29以使逻辑更通顺,翻译时按推测内容给出,供参考。)