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What keeps Kv channels small? The molecular physiology of modesty.

作者信息

Sack Jon T, Tilley Drew C

机构信息

Department of Physiology and Membrane Biology and Department of Anesthesiology and Pain Medicine, University of California, Davis, Davis, CA 95616 Department of Physiology and Membrane Biology and Department of Anesthesiology and Pain Medicine, University of California, Davis, Davis, CA 95616

Department of Physiology and Membrane Biology and Department of Anesthesiology and Pain Medicine, University of California, Davis, Davis, CA 95616.

出版信息

J Gen Physiol. 2015 Aug;146(2):123-7. doi: 10.1085/jgp.201511469.

DOI:10.1085/jgp.201511469
PMID:26216857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4516784/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79dc/4516784/4613b9a888f6/JGP_201511469_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79dc/4516784/be4832e1c1b5/JGP_201511469_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79dc/4516784/4613b9a888f6/JGP_201511469_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79dc/4516784/be4832e1c1b5/JGP_201511469_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79dc/4516784/4613b9a888f6/JGP_201511469_Fig2.jpg

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What keeps Kv channels small? The molecular physiology of modesty.是什么让钾离子通道保持小巧？适度的分子生理学。
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2
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Plant Signal Behav. 2014;9(10):e972892. doi: 10.4161/15592316.2014.972892.
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The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.摇椅式钾通道的孤立电压感应结构域形成一个电压门控阳离子通道。
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引用本文的文献

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PLoS One. 2016 Dec 1;11(12):e0167524. doi: 10.1371/journal.pone.0167524. eCollection 2016.
2
Pore size matters for potassium channel conductance.孔道大小对钾通道电导率至关重要。
J Gen Physiol. 2016 Oct;148(4):277-91. doi: 10.1085/jgp.201611625. Epub 2016 Sep 12.
3
Ion Concentration- and Voltage-Dependent Push and Pull Mechanisms of Potassium Channel Ion Conduction.

本文引用的文献

1
Pore dimensions and the role of occupancy in unitary conductance of Shaker K channels.孔道尺寸及占有率在Shaker钾通道单位电导中的作用
J Gen Physiol. 2015 Aug;146(2):133-46. doi: 10.1085/jgp.201411353.
2
BK channel opening involves side-chain reorientation of multiple deep-pore residues.BK 通道的开启涉及多个深孔残基的侧链重排。
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E79-88. doi: 10.1073/pnas.1321697111. Epub 2013 Dec 23.
3
K⁺ conduction and Mg²⁺ blockade in a shaker Kv-channel single point mutant with an unusually high conductance.
钾通道离子传导的离子浓度和电压依赖性推拉机制
PLoS One. 2016 Mar 7;11(3):e0150716. doi: 10.1371/journal.pone.0150716. eCollection 2016.
Shaker Kv 通道单点突变体中具有异常高电导的 K⁺传导和 Mg²⁺阻断。
Biophys J. 2012 Sep 19;103(6):1198-207. doi: 10.1016/j.bpj.2012.08.015.
4
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.人类 K2P TRAAK 通道的晶体结构，一种脂质和机械敏感性钾离子通道。
Science. 2012 Jan 27;335(6067):436-41. doi: 10.1126/science.1213808.
5
Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.半胱氨酸扫描和修饰揭示了内孔区域 BK 通道和 Kv 通道之间的主要差异。
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12161-6. doi: 10.1073/pnas.1104150108. Epub 2011 Jul 5.
6
Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume.BK 通道内腔小尺寸、低电阻入口由侧链体积变化决定。
J Gen Physiol. 2011 Jun;137(6):533-48. doi: 10.1085/jgp.201110616. Epub 2011 May 16.
7
Crucial points within the pore as determinants of K⁺ channel conductance and gating.孔内的关键点位决定了钾离子通道的电导和门控。
J Mol Biol. 2011 Aug 5;411(1):27-35. doi: 10.1016/j.jmb.2011.04.058. Epub 2011 Apr 30.
8
Closed-channel block of BK potassium channels by bbTBA requires partial activation.BBTBA 对 BK 钾通道的闭通道阻断需要部分激活。
J Gen Physiol. 2009 Nov;134(5):409-36. doi: 10.1085/jgp.200910251.
9
Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block.BK通道孔内的固有静电势：在决定单通道电导和阻断中的作用。
J Gen Physiol. 2008 Feb;131(2):147-61. doi: 10.1085/jgp.200709862.
10
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.脂质膜样环境中电压依赖性钾离子通道的原子结构。
Nature. 2007 Nov 15;450(7168):376-82. doi: 10.1038/nature06265.