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A Not-So-Little Role for Lipoprotein(a) in the Development of Calcific Aortic Valve Disease.

作者信息

Rogers Maximillian A, Aikawa Elena

机构信息

From Center for Interdisciplinary Cardiovascular Sciences (M.A.R., E.A.) and Center for Excellence in Vascular Biology (E.A.), Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

出版信息

Circulation. 2015 Aug 25;132(8):621-3. doi: 10.1161/CIRCULATIONAHA.115.018139. Epub 2015 Jul 29.

DOI:10.1161/CIRCULATIONAHA.115.018139
PMID:26224809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4550561/
Abstract
摘要

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本文引用的文献

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Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.脂蛋白(a)衍生的自分泌酶和瓣间充质细胞促进主动脉瓣炎症和钙化。
Circulation. 2015 Aug 25;132(8):677-90. doi: 10.1161/CIRCULATIONAHA.115.016757. Epub 2015 Jul 29.
2
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events.阿利西尤单抗降低血脂和心血管事件的疗效和安全性。
N Engl J Med. 2015 Apr 16;372(16):1489-99. doi: 10.1056/NEJMoa1501031. Epub 2015 Mar 15.
3
Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability.具有重大影响的小实体：微钙化与动脉粥样硬化斑块易损性
Curr Opin Lipidol. 2014 Oct;25(5):327-32. doi: 10.1097/MOL.0000000000000105.
4
Potential drug targets for calcific aortic valve disease.钙化性主动脉瓣疾病的潜在药物靶点。
Nat Rev Cardiol. 2014 Apr;11(4):218-31. doi: 10.1038/nrcardio.2014.1. Epub 2014 Jan 21.
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Circulation. 2014 Jan 21;129(3):e28-e292. doi: 10.1161/01.cir.0000441139.02102.80. Epub 2013 Dec 18.
6
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Circulation. 2014 Feb 11;129(6):635-42. doi: 10.1161/CIRCULATIONAHA.113.004406. Epub 2013 Nov 17.
7
Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population.脂蛋白(a)水平升高与普通人群主动脉瓣狭窄的风险。
J Am Coll Cardiol. 2014 Feb 11;63(5):470-7. doi: 10.1016/j.jacc.2013.09.038. Epub 2013 Oct 23.
8
Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralization.脂蛋白相关磷脂酶 A2 在钙化性主动脉瓣疾病中的高表达：对瓣膜矿化的影响。
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9
AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment with Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined with Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial.AMG145，一种针对前蛋白转化酶枯草溶菌素 9 的单克隆抗体，可显著降低接受他汀类药物治疗的高胆固醇血症患者的脂蛋白(a)：来自 LDL-C 评估与前蛋白转化酶枯草溶菌素 9 单克隆抗体抑制联合他汀类药物治疗（LAPLACE）-心肌梗死溶栓治疗（TIMI）57 试验的分析。
Circulation. 2013 Aug 27;128(9):962-9. doi: 10.1161/CIRCULATIONAHA.113.001969. Epub 2013 Jul 24.
10
Scavenger receptor-BI is a receptor for lipoprotein(a).清道夫受体-BI 是脂蛋白(a)的受体。
J Lipid Res. 2013 Sep;54(9):2450-7. doi: 10.1194/jlr.M038877. Epub 2013 Jun 29.