Akgün Didar Elif, Avcı Eyüp, Yaman Ali, Şafak Özgen, Kısacık Halil Lütfi, Argan Onur, Yıldırım Seda Elçim, Yıldırım Tarık, Naser Abdulrahman, Gençbay Murat, Kırış Tuncay
Department of Cardiology, Kırklareli Training and Research Hospital, Kırklareli, Türkiye.
Department of Cardiology, Balıkesir University Faculty of Medicine, Balıkesir, Türkiye.
Anatol J Cardiol. 2024 Jan 7;28(2):102-8. doi: 10.14744/AnatolJCardiol.2023.3695.
Endocan is an indicator of many pathologies accompanied by inflammation, endothelial cell activation, and dysfunction. In this study, we examined the relationship between degenerative aortic sclerosis, which progresses in a similar pathophysiologic mechanism as atherosclerosis, and serum inflammatory markers and endocan levels.
A total of 155 patients without known coronary artery disease, aged between 65 and 80 years, were consecutively included in the prospective cross-sectional study. The study population was analyzed in 4 different groups. The control group consisted of patients with normal aortic valve structure, while patients with aortic stenosis were classified as mild aortic stenosis (2-2.9 m/s), moderate aortic stenosis (3-3.9 m/s), and severe aortic stenosis (≥ 4 m/s) according to their aortic velocity. While there were 39 patients in the control group, there were 58, 24, and 34 patients in the mild, moderate, and severe aortic stenosis groups, respectively.
There was no statistically significant difference between the groups in terms of patient distribution and characteristics. History of dyspnea and angina was correlated with the severity of aortic stenosis (P <.001). In this study, no statistically significant correlation was found between serum endocan levels and the severity of aortic stenosis (control group: 17.3 ± 6.3 ng/mL, mild aortic stenosis: 17.6 ± 8.7 ng/mL, moderate aortic stenosis: 16.3 ± 3.8 ng/mL, severe aortic stenosis: 15.2 ± 5.9 ng/mL, P =.396). However, it was figured out that there was a positive correlation between endocan levels and hemoglobin (Hg) (r = 0.308, P =.001), platelet (PLT) (r = 0.320, P <.001), and albumin (Alb) (r = 0.206, P =.026).
In this study, no significant correlation was found between serum endocan levels and the severity of aortic stenosis. On the other hand, there was a positive correlation between endocan levels and Hg, PLT, and Alb.
内脂素是许多伴有炎症、内皮细胞活化和功能障碍的病理状态的指标。在本研究中，我们研究了与动脉粥样硬化具有相似病理生理机制的退行性主动脉硬化与血清炎症标志物和内脂素水平之间的关系。
共有155例年龄在65至80岁之间、无已知冠状动脉疾病的患者连续纳入前瞻性横断面研究。研究人群被分为4个不同组。对照组由主动脉瓣结构正常的患者组成，而主动脉狭窄患者根据其主动脉流速被分类为轻度主动脉狭窄（2 - 2.9米/秒）、中度主动脉狭窄（3 - 3.9米/秒）和重度主动脉狭窄（≥4米/秒）。对照组有39例患者，轻度、中度和重度主动脉狭窄组分别有58例、24例和34例患者。
在患者分布和特征方面，各组之间无统计学显著差异。呼吸困难和心绞痛病史与主动脉狭窄的严重程度相关（P <.001）。在本研究中，未发现血清内脂素水平与主动脉狭窄严重程度之间存在统计学显著相关性（对照组：17.3±6.3纳克/毫升，轻度主动脉狭窄：17.6±8.7纳克/毫升，中度主动脉狭窄：16.3±3.8纳克/毫升，重度主动脉狭窄：15.2±5.9纳克/毫升，P =.396）。然而，发现内脂素水平与血红蛋白（Hg）（r = 0.308，P =.001）、血小板（PLT）（r = 0.320，P <.001）和白蛋白（Alb）（r = 0.206，P =.026）之间存在正相关。
在本研究中，未发现血清内脂素水平与主动脉狭窄严重程度之间存在显著相关性。另一方面，内脂素水平与Hg、PLT和Alb之间存在正相关。
