Frank O, Klein W, Kocsis F, Altmann H
Aktuelle Gerontol. 1977 Dec;7(12):629-31.
Relations between the time of manifestation of the disease and the course of the rheumatoid arthritis were found from the clinic frequently. Patients with later first manifestation of rheumatoid arthritis show clear differences against patients with earlier manifestation of the disease at which the late first manifestation a high activity of the process of the disease exhibit. In males first manifestation of rheumatoid arthritis in middle age of 54,5 years was observed, while in a first manifestation of rheumatoid arthritis in middle age of 47 years a normal course of the disease was found. The difference between the both courses was proved as significantly. In former investigations we could prove that in patients with rheumatoid arthritis the 3H-Thymidin-build in the course of not programmed DNA-synthesis in the DNA of lymphocytes after damage with ionizing was retarded. The rate of not programmed DNA synthesis seems to be in old persons equal. The ligase reaction is possibly diminished because the number of DNA-strand breakes with the age is strong increasing.
临床上经常发现疾病表现时间与类风湿性关节炎病程之间的关系。类风湿性关节炎首发表现较晚的患者与首发表现较早的患者存在明显差异，前者疾病进程具有较高的活动度。在男性中，观察到类风湿性关节炎的首发年龄为54.5岁，而在首发年龄为47岁时，疾病进程正常。两者病程之间的差异被证明具有显著性。在之前的研究中，我们能够证明，类风湿性关节炎患者在受到电离辐射损伤后，淋巴细胞DNA中未程序化DNA合成过程中的3H-胸腺嘧啶核苷掺入受到阻碍。未程序化DNA合成的速率在老年人中似乎是相同的。连接酶反应可能会减弱，因为随着年龄增长，DNA链断裂的数量大幅增加。
