Partsch G, Schwarzer C, Tausch G, Eberl R
Aktuelle Gerontol. 1977 Dec;7(12):621-8.
The amino acids of blood plasma of 43 patients with rheumatoid arthritis (RA) and 19 controls were investigated by ion exchange chromatography. It was proofed simultaneously whether human more than 60 years old exhibit significantly different amino acid concentrations from younger individuals. It was found that RA patients more than 60 years differ significantly in 23 out of 30 amino acids. Only Asparagine was decreased, all other amino acids were increased. The controls did not show the same uniform direction of results. Older individuals exhibited differences in only 14 amino acids. Phosphoserine, Cystathionine and Arginine were increased to a great extent while Threonine, 1-Methylhistidine and Tryptophane were apparently diminished in this group of age.
采用离子交换色谱法对43例类风湿性关节炎（RA）患者和19名对照者的血浆氨基酸进行了研究。同时验证了60岁以上人群的氨基酸浓度是否与年轻个体存在显著差异。结果发现，60岁以上的RA患者在30种氨基酸中有23种存在显著差异。只有天冬酰胺减少，其他所有氨基酸均增加。对照组未呈现相同的一致结果方向。老年个体仅在14种氨基酸上存在差异。在该年龄组中，磷酸丝氨酸、胱硫醚和精氨酸大幅增加，而苏氨酸、1-甲基组氨酸和色氨酸明显减少。
