Bauer K, Partsch G, Tausch G, Eberl R, Moser K, Deutsch E
Z Rheumatol. 1978 Jul-Aug;37(7-8):260-6.
Protein synthesis in lymphocytes of patients suffering from rheumatoid arthritis shows various levels according to the stage of the disease. Incorporation of 3H-isoleucine is markedly increased in progredient cases (compared to normal subjects + 75%). Additional treatment of these patients with corticosteroids has no effect on the protein synthesis in the lymphocytes. This seems to be in contrast to investigations using in vitro incubation of lymphocytes in media containing steroids. Because of completely different conditions in these investigations exact comparison of the results is not possible. Protein synthesis in lymphocytes from patients with early stages of rheumatoid arthritis or ankylosing spondylitis shows no statistically significant difference to normal controls.
类风湿性关节炎患者淋巴细胞中的蛋白质合成根据疾病阶段呈现出不同水平。在病情进展期病例中，3H-异亮氨酸的掺入量显著增加（与正常受试者相比增加75%）。用皮质类固醇对这些患者进行额外治疗对淋巴细胞中的蛋白质合成没有影响。这似乎与在含类固醇培养基中对淋巴细胞进行体外培养的研究结果相反。由于这些研究中的条件完全不同，因此无法对结果进行精确比较。类风湿性关节炎或强直性脊柱炎早期患者淋巴细胞中的蛋白质合成与正常对照组相比，在统计学上没有显著差异。
