Katsumata T, Kohno S, Yamaguchi K, Hara K, Aoki Y
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Parasitol Res. 1989;76(1):90-1. doi: 10.1007/BF00931079.
The effect of calcium channel blockers (diltiazem and verapamil) and a calmodulin antagonist (W-7) on the hatching of Schistosoma mansoni eggs in fresh water was studied. The hatching of the eggs was inhibited by diltiazem and W-7 in a dose-dependent fashion and only slightly by verapamil. The present study indicates that the hatching of S. mansoni eggs is a Ca2+/calmodulin-dependent process.