Kawase Ishihara Kayoko, Kokubo Yoshihiro, Yokota Chiaki, Hida Eisuke, Miyata Toshiyuki, Toyoda Kazunori, Matsumoto Masayasu, Minematsu Kazuo, Miyamoto Yoshihiro
Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan; Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
J Stroke Cerebrovasc Dis. 2015 Oct;24(10):2385-9. doi: 10.1016/j.jstrokecerebrovasdis.2015.06.039. Epub 2015 Jul 30.
Few studies have reported on the association between inflammatory markers and atherosclerosis by smoking status. We investigated the effect of plasma levels of fibrinogen and high-sensitive C-reactive protein (hsCRP) on subclinical atherosclerosis stratified by smoking in a general urban population.
From participants of the Suita study without a history of cardiovascular diseases, a total of 2502 subjects (805 men, median age 64 years) who underwent carotid ultrasonography were enrolled. Subjects were divided into current smokers (n = 566) and never-smokers. Ex-smokers were not included in the study. Each group was subdivided according to the median levels of markers (plasma fibrinogen [2.99 g/L] and hsCRP [.51 mg/L]) and the smoking amounts. We compare the adjusted maximum and mean intima-media thickness (IMT).
In men and women, maximum IMT and mean IMT of the high fibrinogen and high hsCRP (Fib(H)CRP(H)) with smoking were thicker than those of the low fibrinogen and low hsCRP (Fib(L)CRP(L)) without smoking, the Fib(L)CRP(L) with smoking, and the Fib(H)CRP(H) without smoking after adjusting for covariates. The Fib(L)CRP(L) with smoking had thicker IMTs than the Fib(L)CRP(L) without smoking. There was a dose-dependent smoking effect on IMT in men. These trends were similar in age 60, 65, and 70.
Plasma fibrinogen and hsCRP levels were related to multivariate-adjusted IMT, and smoking was associated with IMT in men. The combination of plasma fibrinogen and hsCRP levels could be a potential marker on subclinical carotid atherosclerosis in urban people.
很少有研究报道炎症标志物与吸烟状态下动脉粥样硬化之间的关联。我们在一般城市人群中研究了纤维蛋白原和高敏C反应蛋白（hsCRP）血浆水平对按吸烟情况分层的亚临床动脉粥样硬化的影响。
从没有心血管疾病病史的吹田研究参与者中，纳入了2502名接受颈动脉超声检查的受试者（805名男性，中位年龄64岁）。受试者分为当前吸烟者（n = 566）和从不吸烟者。既往吸烟者未纳入本研究。每组根据标志物（血浆纤维蛋白原[2.99 g/L]和hsCRP[0.51 mg/L]）的中位水平和吸烟量进一步细分。我们比较了调整后的最大和平均内膜中层厚度（IMT）。
在男性和女性中，校正协变量后，吸烟的高纤维蛋白原和高hsCRP（Fib(H)CRP(H)）组的最大IMT和平均IMT比不吸烟的低纤维蛋白原和低hsCRP（Fib(L)CRP(L)）组、吸烟的Fib(L)CRP(L)组以及不吸烟的Fib(H)CRP(H)组更厚。吸烟的Fib(L)CRP(L)组的IMT比不吸烟的Fib(L)CRP(L)组更厚。男性中吸烟对IMT有剂量依赖性影响。在60岁、65岁和70岁人群中这些趋势相似。
血浆纤维蛋白原和hsCRP水平与多变量调整后的IMT相关，且吸烟与男性的IMT相关。血浆纤维蛋白原和hsCRP水平的组合可能是城市人群亚临床颈动脉粥样硬化的潜在标志物。
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