Saowakon Naruwan, Ngernsoungnern Piyada, Watcharavitoon Pornpun, Ngernsoungnern Apichart, Kosanlavit Rachain
School of Anatomy, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.
School of Occupational Health and Safety, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.
Environ Sci Pollut Res Int. 2015 Dec;22(23):19002-12. doi: 10.1007/s11356-015-5078-2. Epub 2015 Aug 2.
Cadavers are usually preserved by embalming solution which is composed of formaldehyde (FA), phenol, and glycerol. Therefore, medical students and instructors have a higher risk of exposure to FA inhalation from cadavers during dissection. Therefore, the objective of this study was to evaluate the FA exposure in indoor air and breathing zone of medical students and instructors during dissection classes in order to investigate the relationship between them. The indoor air and personal air samples in breathing zone were collected three times during anatomy dissection classes (in January, August, and October of 2014) with sorbent tubes, which were analyzed by high-performance liquid chromatography (HPLC). The air cleaner machines were determined by weight measurement. Pulmonary function tests and irritation effects were also investigated. The mean of FA concentrations ranged from 0.117 to 0.415 ppm in the indoor air and from 0.126 to 1.176 ppm in the breathing zone of students and instructors. All the personal exposure data obtained exceeded the threshold limit of NIOSH and WHO agencies. The air cleaner machines were not significant difference. The pulmonary function of instructors showed a decrease during attention of classes and statistically significant decreasing in the instructors more than those of the students. Clinical symptoms that were observed in nose and eyes were irritations with general fatigue. We suggested that the modified exhaust ventilation and a locally ventilated dissection work table were considered for reducing FA levels in the gross anatomy dissection room.
尸体通常用由甲醛(FA)、苯酚和甘油组成的防腐液保存。因此,医学生和教师在解剖过程中接触来自尸体的吸入性FA的风险更高。因此,本研究的目的是评估解剖课期间医学生和教师室内空气和呼吸区域中的FA暴露情况,以调查它们之间的关系。在解剖课期间(2014年1月、8月和10月),使用吸附管对呼吸区域的室内空气和个人空气样本进行了三次采集,并用高效液相色谱法(HPLC)进行分析。通过重量测量确定空气净化机器。还调查了肺功能测试和刺激效应。室内空气中FA浓度的平均值在0.117至0.415 ppm之间,学生和教师呼吸区域中的FA浓度在0.126至1.176 ppm之间。获得的所有个人暴露数据均超过了美国国家职业安全与健康研究所(NIOSH)和世界卫生组织(WHO)机构的阈值限制。空气净化机器没有显著差异。教师的肺功能在上课期间有所下降,并且教师的下降在统计学上比学生更显著。在鼻子和眼睛观察到的临床症状是刺激和全身疲劳。我们建议考虑改进排气通风和局部通风的解剖工作台,以降低大体解剖室中的FA水平。