Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China.
Obesity (Silver Spring). 2015 Sep;23(9):1929-37. doi: 10.1002/oby.21182. Epub 2015 Aug 4.
The ultrasound quantitative method for liver fat content (LFC) is a recent established method for non-invasive assessment of liver steatosis. Its use in clinical practice is further explored by investigating the quantitative relationships between LFC measured by quantitative ultrasonography and metabolic diseases in a middle-aged and elderly Chinese population.
Liver fat content was measured by the quantitative ultrasound method in 4,916 participants from the Shanghai Changfeng Community Study. The anthropometric and serum biochemical parameters related to glucose and lipid metabolism were detected for each participant. The carotid artery intima-media thickness (CIMT) was measured by ultrasonography.
The LFC displayed a non-Gaussian and positively skewed distribution in the community population and was significantly correlated with body weight, serum glucose, lipid profile, and CIMT. The 95th percentile of LFC in the subgroup of participants without any metabolic disease was 10.8%, and a LFC ≥ 10% was correlated with remarkable increases in the risks for glucose and lipid metabolic diseases.
The quantitative ultrasound method that was developed for measuring LFC was useful in a population study. A LFC ≥ 10% might help to identify the subjects with an increased risk for metabolic diseases.
肝脏脂肪含量（LFC）的超声定量方法是一种新近建立的用于非侵入性评估肝脂肪变性的方法。通过调查定量超声测量的 LFC 与中年和老年中国人群中代谢疾病之间的定量关系，进一步探讨其在临床实践中的应用。
在上海长风社区研究中，对 4916 名参与者使用定量超声方法测量肝脏脂肪含量。为每位参与者检测与葡萄糖和脂质代谢相关的人体测量学和血清生化参数。通过超声测量颈动脉内膜中层厚度（CIMT）。
社区人群中 LFC 呈非正态和正偏态分布，与体重、血清葡萄糖、血脂谱和 CIMT 显著相关。无任何代谢疾病的参与者亚组中 LFC 的第 95 百分位数为 10.8%，LFC≥10%与葡萄糖和脂质代谢疾病风险显著增加相关。
用于测量 LFC 的定量超声方法在人群研究中是有用的。LFC≥10%可能有助于识别代谢疾病风险增加的受试者。
