Wang Dan, Lin Huandong, Xia Mingfeng, Aleteng Qiqige, Li Xiaoming, Ma Hui, Pan Baishen, Gao Jian, Gao Xin
Department of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Institute of Chronic Metabolic Diseases, Fudan University, Shanghai 200032, China.
Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032 China.
PLoS One. 2016 Jun 10;11(6):e0157515. doi: 10.1371/journal.pone.0157515. eCollection 2016.
BACKGROUND/OBJECTIVES: Vitamin D exerts metabolic activities. We investigated whether the 25-hydroxy vitamin D [25(OH)D] is associated with liver fat content (LFC) and non-alcoholic fatty liver disease (NAFLD) in a middle-aged, elderly Chinese population.
SUBJECT/METHODS: A total of 2,960 participants (954 men and 2,006 women) aged over 45 years old were enrolled. Each participant underwent a standard interview, anthropometric measurements and laboratory examinations. Vitamin D deficiency and insufficiency was diagnosed when serum 25(OH) D level was < 50 and 50-75nmol/L. An ultrasound quantitative method was used to assess the LFC.
Among the 2,960 participants, 1,982 (67.0%) subjects had vitamin D deficiency, 769 (26.0%) had vitamin D insufficiency, and 209 (7%) had normal vitamin D. Male subjects with vitamin D deficiency and insufficiency had significantly higher LFC than those with normal 25(OH)D (P = 0.034), while the LFC values showed no significant difference among the female subjects with vitamin D sufficiency, insufficiency and deficiency (P = 0.396). Univariate correlation analysis showed that 25(OH)D had a significantly negative association with LFC in men (r = -0.085, P = 0.009), but not in women. After adjusting for age, cigarette smoking, examination season, serum calcium, PTH and all possible confounders that displayed significant associations with LFC in univariate correlation analysis, serum 25(OH)D remained associated with LFC in middle-aged and elderly Chinese men.
Serum 25(OH)D level was inversely associated with LFC in middle-aged and elderly Chinese men.
背景/目的：维生素D具有代谢活性。我们调查了在中老年中国人群中，25-羟基维生素D[25(OH)D]是否与肝脏脂肪含量（LFC）及非酒精性脂肪性肝病（NAFLD）相关。
对象/方法：共纳入2960名年龄超过45岁的参与者（954名男性和2006名女性）。每位参与者均接受了标准访谈、人体测量和实验室检查。当血清25(OH)D水平<50和50 - 75nmol/L时，分别诊断为维生素D缺乏和不足。采用超声定量法评估LFC。
在2960名参与者中，1982名（67.0%）受试者存在维生素D缺乏，769名（26.0%）存在维生素D不足，209名（7%）维生素D正常。维生素D缺乏和不足的男性受试者的LFC显著高于25(OH)D正常的男性（P = 0.034），而维生素D充足、不足和缺乏的女性受试者的LFC值无显著差异（P = 0.396）。单因素相关性分析显示，25(OH)D与男性的LFC呈显著负相关（r = -0.085，P = 0.009），而与女性无关。在调整年龄、吸烟、检查季节、血清钙、甲状旁腺激素以及在单因素相关性分析中与LFC显示出显著关联的所有可能混杂因素后，血清25(OH)D在中老年中国男性中仍与LFC相关。
中老年中国男性的血清25(OH)D水平与LFC呈负相关。
