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一种优化的半自动速率法测定血清谷胱甘肽还原酶活性及其在恶性疾病患者中的应用

An optimized semi-automatic rate method for serum glutathione reductase activity and its application to patients with malignant disease.

作者信息

Delides A, Spooner R J, Goldberg D M, Neal F E

出版信息

J Clin Pathol. 1976 Jan;29(1):73-7. doi: 10.1136/jcp.29.1.73.

DOI:10.1136/jcp.29.1.73
PMID:2624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC475950/
Abstract

An improved and optimized method for serum glutathione reductase is described. The reference range for normal subjects is 47-79 IU/1. The method is more sensitive than conventional enzyme tests in the detection of malignant disease. It was not raised more frequently in patients with clinical evidence of metastases than in those clinically free of such metastases, and it did not seem to correlate with prognosis among those patients who failed to survive six months from the time the analysis was first conducted.

摘要

本文描述了一种改进和优化的血清谷胱甘肽还原酶检测方法。正常受试者的参考范围为47 - 79 IU/1。该方法在检测恶性疾病方面比传统酶检测更敏感。有转移临床证据的患者中，该指标升高的频率并不比无此类转移的患者更高，而且在首次进行分析后未能存活六个月的患者中，该指标似乎与预后无关。

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An optimized semi-automatic rate method for serum glutathione reductase activity and its application to patients with malignant disease.一种优化的半自动速率法测定血清谷胱甘肽还原酶活性及其在恶性疾病患者中的应用
J Clin Pathol. 1976 Jan;29(1):73-7. doi: 10.1136/jcp.29.1.73.
2
[Optimized determination and properties of NADPH-dependent glutathione reductase in serum. Studies on serum glutathione reductase, I. (author's transl)].血清中NADPH依赖性谷胱甘肽还原酶的优化测定及特性。血清谷胱甘肽还原酶的研究，I.（作者译）
Z Klin Chem Klin Biochem. 1975 Mar;13(3):123-8.
3
[Colorimetric method of determination of the erythrocyte glutathione reductase activity and its use in the enzymatic test for detection of riboflavin deficiency].[红细胞谷胱甘肽还原酶活性的比色测定方法及其在核黄素缺乏检测酶试验中的应用]
Rocz Panstw Zakl Hig. 1979;30(4):349-58.
4
[Erythrocyte glutathione reductase (EGR)].
Nihon Rinsho. 2004 Dec;62 Suppl 12:809-11.
5
Method for the detection of a biochemical riboflavin deficiency. Stimulation of NADPH2-dependent glutathione reductase from human erythrocytes by FAD in vitro. Investigations on the vitamin B2 status in healthly people and geriatric patients.检测生化性核黄素缺乏的方法。体外FAD对人红细胞中NADPH2依赖性谷胱甘肽还原酶的刺激作用。对健康人群和老年患者维生素B2状态的研究。
Int Z Vitaminforsch. 1970;40(2):166-83.
6
[Determination of glutathione reductase activity in erythrocytes and whole blood as an indicator of riboflavin nutrition].[测定红细胞和全血中谷胱甘肽还原酶活性作为核黄素营养指标]
Acta Vitaminol Enzymol. 1983;5(3):171-8.
7
Effect of riboflavin depletion and repletion on the erythrocyte glutathione reductase in the rat.核黄素缺乏与补充对大鼠红细胞谷胱甘肽还原酶的影响。
J Nutr. 1971 Nov;101(11):1459-66. doi: 10.1093/jn/101.11.1459.
8
Erythrocyte glutathione reductase--a measure of riboflavin nutritional status.红细胞谷胱甘肽还原酶——核黄素营养状况的一种衡量指标。
Nutr Rev. 1972 Jul;30(7):162-4. doi: 10.1111/j.1753-4887.1972.tb04027.x.
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[Interference by glutathione reductase in the "CK-MB-inhibition-test": elimination of the catalytic activity of glutathione reductase by anti-glutathione reductase (author's transl)].[谷胱甘肽还原酶在“CK-MB抑制试验”中的干扰作用：抗谷胱甘肽还原酶消除谷胱甘肽还原酶的催化活性（作者译）]
J Clin Chem Clin Biochem. 1978 Apr;16(4):253-4.
10
[Optimization of determining human erythrocyte glutathione reductase activity using a semiautomatic analyzer].[使用半自动分析仪测定人红细胞谷胱甘肽还原酶活性的优化]
Vopr Med Khim. 1994 Mar-Apr;40(2):59-61.

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本文引用的文献

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Serum TPN-linked enzymes glucose-6-phosphate dehydrogenase, isocitric dehydrogenase and glutathione reductase activities in health and in various disease states.健康及各种疾病状态下血清中与全胃肠外营养相关的酶（葡萄糖-6-磷酸脱氢酶、异柠檬酸脱氢酶和谷胱甘肽还原酶）的活性。
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PURIFICATION AND PROPERTIES OF GLUTATHIONE REDUCTASE OF HUMAN ERYTHROCYTES.人红细胞谷胱甘肽还原酶的纯化及性质
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A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency.一系列针对丙酮酸激酶缺乏症、葡萄糖-6-磷酸脱氢酶缺乏症和谷胱甘肽还原酶缺乏症的新筛查程序。
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Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies.黄素化合物对谷胱甘肽还原酶活性的影响：体内和体外研究
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Enzymatic test for the detection of a riboflavin deficiency. NADPH-dependent glutathione reductase of red blood cells and its activation by FAD in vitro.用于检测核黄素缺乏的酶促试验。红细胞中依赖NADPH的谷胱甘肽还原酶及其在体外被FAD激活的情况。
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A serum alkaline phosphatase isoenzyme of human neoplastic cell origin.一种源自人类肿瘤细胞的血清碱性磷酸酶同工酶。
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Automated reaction rate analysis of erythrocyte glucose-6-phosphate dehydrogenase and glutathione reductase activities.红细胞葡萄糖-6-磷酸脱氢酶和谷胱甘肽还原酶活性的自动反应速率分析
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Thyroid hormone control of glutathione reductase activity in rat erythrocytes and liver.
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