外排体复合物概述
The Exocyst at a Glance.
作者信息
Wu Bin, Guo Wei
机构信息
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
出版信息
J Cell Sci. 2015 Aug 15;128(16):2957-64. doi: 10.1242/jcs.156398. Epub 2015 Aug 3.
Abstract
The exocyst is an octameric protein complex that is implicated in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal control of exocytosis through the exocyst has a crucial role in a number of physiological processes, such as morphogenesis, cell cycle progression, primary ciliogenesis, cell migration and tumor invasion. In this Cell Science at a Glance poster article, we summarize recent works on the molecular organization, function and regulation of the exocyst complex, as they provide rationales to the involvement of this complex in such a diverse array of cellular processes.
摘要
外泌体是一种八聚体蛋白复合物，在SNARE介导的融合之前，它参与将分泌小泡拴系到质膜上。通过外泌体对胞吐作用进行空间和时间控制在许多生理过程中起着关键作用，如形态发生、细胞周期进程、初级纤毛发生、细胞迁移和肿瘤侵袭。在这篇“细胞科学一览”海报文章中，我们总结了关于外泌体复合物的分子组织、功能和调节的最新研究成果，因为它们为该复合物参与如此多样的细胞过程提供了理论依据。
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