Akimoto Shunsuke, Nandipati Kalyana C, Kapoor Harit, Yamamoto Se Ryung, Pallati Pradeep K, Mittal Sumeet K
Department of Surgery, Creighton University Medical Center, 601 North 30th Street, Suite 3700, Omaha, NE, 68131, USA.
J Gastrointest Surg. 2015 Nov;19(11):1943-8. doi: 10.1007/s11605-015-2907-z. Epub 2015 Aug 5.
Obesity has been implicated as an important risk factor for fundoplication failure. However, the mechanism of fundoplication in obese patients is not fully understood. Our objective is to evaluate the patterns of failure in relation to the body mass index (BMI) undergoing re-operative intervention after failed fundoplication.
After Institutional Review Board approval, the patients who underwent re-operative intervention for failed fundoplication between November 2008 and December 2013 were identified. Patients were classified into three groups: non-obese, obese, and morbidly obese (<30, 30-35, >35 BMI, respectively). Pre-operative assessment and operative procedure performed were compared between the groups.
One hundred twenty-four patients satisfied study criteria. Non-obese patients (53.2 %) had significantly more dysphagia as an indication for re-operative procedure (obese 31.6 %, p < 0.05; morbidly 16.7 %, p < 0.05). Obese and morbidly obese patients had significantly higher incidence of recurrent hiatal hernia than non-obese patients (88.7 vs. 65.6 %, p < 0.05). Morbidly obese patients had significantly higher incidence of disrupted fundoplication than non-obese patients (41.7 vs. 19.4 %, p < 0.05).
Similar anatomical failure patterns of state of fundoplication and recurrent hiatal hernia were noted between obese patients and morbidly obese patients and were distinct from non-obese patients.
肥胖被认为是胃底折叠术失败的一个重要危险因素。然而,肥胖患者胃底折叠术的机制尚未完全明确。我们的目的是评估胃底折叠术失败后接受再次手术干预的患者中,失败模式与体重指数(BMI)之间的关系。
经机构审查委员会批准,确定了2008年11月至2013年12月期间因胃底折叠术失败而接受再次手术干预的患者。患者分为三组:非肥胖组、肥胖组和病态肥胖组(BMI分别<30、30 - 35、>35)。比较了各组术前评估和实施的手术操作。
124例患者符合研究标准。非肥胖患者(53.2%)因吞咽困难作为再次手术指征的比例显著更高(肥胖组为31.6%,p<0.05;病态肥胖组为16.7%,p<0.05)。肥胖和病态肥胖患者复发性食管裂孔疝的发生率显著高于非肥胖患者(88.7%对65.6%,p<0.05)。病态肥胖患者胃底折叠术破裂的发生率显著高于非肥胖患者(41.7%对19.4%,p<0.05)。
肥胖患者和病态肥胖患者在胃底折叠术状态和复发性食管裂孔疝方面的解剖学失败模式相似,且与非肥胖患者不同。