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Association between walking and hip fracture in women aged 65 and older: 20-year follow-up from the study of osteoporotic fractures.

作者信息

Liu Enwu, Liu Ryan Yan, Moraros John, McCloskey Eugene V, Harvey Nicholas C, Lorentzon Mattias, Johansson Helena, Kanis John A

机构信息

College of Medicine and Public Health, Flinders University, Adelaide, Australia.

School of Science, Suzhou Municipal Key Lab of AI4Health, Xi'an Jiaotong-Liverpool University, Suzhou, China.

出版信息

Osteoporos Int. 2025 May 7. doi: 10.1007/s00198-025-07508-y.


DOI:10.1007/s00198-025-07508-y
PMID:40332499
Abstract

UNLABELLED: Hip fractures in elderly women pose significant healthcare challenges. Promoting walking for exercise as a cost-effective intervention may help reduce the risk of fractures in this population. PURPOSE: This study aimed to examine the relationship between walking and hip fracture risk among women aged 65 years and older. METHODS: A 20-year prospective study (1986-2006) included 9704 women from the Study of Osteoporotic Fractures (SOF) in the USA. Participants were followed biennially, and walking exposure was assessed by the number of city blocks walked for exercise, routine activity, and total blocks walked daily. Cox regression models with time-varying covariates assessed associations, with competing risks addressed using Fine and Gray models. Penalized splines were used to explore dose-response relationships. RESULTS: In total, 1419 hip fractures were identified through the study period. The mean and median follow-up times for hip fractures or censoring were 15.0 and 15.8 years in the walking for exercise group, vs. 13.2 and 13.7 years in the not walking for exercise group. The hip fracture incidence rate was 10.0 cases per 1000 person-years (py) in the walking for exercise group compared to 10.9 per 1000 py in the not walking for exercise group. All-cause mortality was 37.1 per 1000 py in the walking for exercise group compared to 46.4 per 1000 py in the not walking for exercise group. Adjusted models showed that walking for exercise significantly reduced hip fracture risk (HR, 0.864; 95% CI, 0.762-0.980; P = 0.0230), with each additional block walked for exercise reducing risk (HR per block, 0.986; 95% CI, 0.978-0.995; P = 0.0022). Walking for routine activities showed no significant association. Spline analysis indicated walking 16 blocks (≈3200 steps) daily significantly lowered hip fracture risk. CONCLUSION: Walking for exercise is linked to a reduced risk of hip fractures in elderly women. Walking the equivalent of 16 blocks or more (> 3200 steps) per day might be an effective way to reduce the risk of hip fractures in this vulnerable population.

摘要

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[1]
Association between walking and hip fracture in women aged 65 and older: 20-year follow-up from the study of osteoporotic fractures.

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本文引用的文献

[1]
High physical activity is associated with greater cortical bone size, better physical function, and with lower risk of incident fractures independently of clinical risk factors in older women from the SUPERB study.

J Bone Miner Res. 2024-9-2

[2]
Patient Self-Assessment of Walking Ability and Fracture Risk in Older Australian Adults.

JAMA Netw Open. 2024-1-2

[3]
A meta-analysis of previous falls and subsequent fracture risk in cohort studies.

Osteoporos Int. 2024-3

[4]
Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.

Osteoporos Int. 2023-12

[5]
Organisational factors associated with hospital costs and patient mortality in the 365 days following hip fracture in England and Wales (REDUCE): a record-linkage cohort study.

Lancet Healthy Longev. 2023-8

[6]
Effects of physical exercise on physical function in older adults in residential care: a systematic review and network meta-analysis of randomised controlled trials.

Lancet Healthy Longev. 2023-6

[7]
Determinants of age-related decline in walking speed in older women.

PeerJ. 2023

[8]
Dose-Response Relationships between Objectively Measured Daily Steps and Mortality among Frail and Nonfrail Older Adults.

Med Sci Sports Exerc. 2023-6-1

[9]
The clinician's guide to prevention and treatment of osteoporosis.

Osteoporos Int. 2022-10

[10]
Effect of a Home-Based, Walking Exercise Behavior Change Intervention vs Usual Care on Walking in Adults With Peripheral Artery Disease: The MOSAIC Randomized Clinical Trial.

JAMA. 2022-4-12

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