Sezione di Medicina Interna e Angiologia, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
Healthy Lifestyle Institute CURIAMO, Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy.
Osteoporos Int. 2019 Apr;30(4):797-806. doi: 10.1007/s00198-019-04908-9. Epub 2019 Feb 26.
Osteoporosis is a health issue in postmenopausal women. Physical activity is recommended in these subjects, since it has positive effects on bone mass. Cellular mechanisms underlying this effect are still unclear. Osteogenic cells, released after physical exertion, could be a key factor in exercise-induced bone formation.
The aim of our research was to explore if a weight-bearing and resistance exercise program could positively affect circulating osteogenic cells (OCs), markers of bone formation and quality of life (QoL) in osteopenic postmenopausal women.
We recruited 33 postmenopausal women with a T-score at lumbar spine or femoral neck between - 1 and - 2.5 SD. Anthropometric and fitness parameters, bone-remodeling markers, OCs, and QoL were evaluated at the time of enrolment, after 1-month run-in period, and after 3 months of weight-bearing and resistance exercise.
After 3 months of training, the pro-collagen type 1 N-terminal peptide (P1NP) and the number of OCs were significantly increased, with no significant increase of the type 1 collagen cross-linked C-telopeptide (sCTX). We also observed a significant increase in body height, one-repetition maximum (1RM) on the pull-down lat machine and leg press, and mean VOmax. The increase of immature circulating OCs was significantly correlated with the improvement of 1RM both of the upper and lower limbs. Moreover, QoL was significantly improved with regard to pain, physical function, mental function, and general QoL. The improvement in QoL, namely in the overall score and in the pain score, was significantly correlated with the increase in height.
The exercise program we trialed is able to increase the markers of bone formation and the commitment of immature OCs with no significant increase in the markers of bone resorption. Our results confirm that combined weight-bearing and resistance physical activity is an effective tool to improve QoL of postmenopausal women with low bone mass.
NCT03195517.
我们的研究旨在探讨负重和抗阻运动方案是否能对骨量减少的绝经后女性的循环成骨细胞（OCs）、骨形成标志物和生活质量（QoL）产生积极影响。
我们招募了 33 名腰椎或股骨颈 T 评分在-1 到-2.5 SD 的绝经后女性。在招募时、1 个月的适应期后以及 3 个月的负重和抗阻运动后，评估了人体测量和体能参数、骨重建标志物、OCs 和 QoL。
经过 3 个月的训练，前胶原类型 1 N 端肽（P1NP）和 OCs 的数量明显增加，而 1 型胶原交联 C 端肽（sCTX）没有明显增加。我们还观察到身高、下拉机 1 次重复最大（1RM）和腿推力量的显著增加，以及平均 VOmax 的增加。不成熟循环 OCs 的增加与上下肢 1RM 的改善显著相关。此外，疼痛、身体机能、精神机能和总体 QoL 均显著改善。QoL 的改善，即总体评分和疼痛评分，与身高的增加显著相关。
我们试验的运动方案能够增加骨形成标志物和不成熟 OCs 的分化，而不会显著增加骨吸收标志物。我们的结果证实，联合负重和抗阻体力活动是改善低骨量绝经后女性 QoL 的有效工具。
