Aryal Krishna Kumar, Mehata Suresh, Neupane Sushhama, Vaidya Abhinav, Dhimal Meghnath, Dhakal Purushottam, Rana Sangeeta, Bhusal Chop Lal, Lohani Guna Raj, Paulin Frank Herbert, Garg Renu Madanlal, Guthold Regina, Cowan Melanie, Riley Leanne Margaret, Karki Khem Bahadur
Nepal Health Research Council (NHRC), Government of Nepal, Kathmandu, Nepal.
Nepal Health Sector Support Programme (NHSSP), Ministry of Health and Population, Government of Nepal, Kathmandu, Nepal.
PLoS One. 2015 Aug 5;10(8):e0134834. doi: 10.1371/journal.pone.0134834. eCollection 2015.
World Health Organization (WHO) estimates for deaths attributed to Non Communicable Diseases (NCDs) in Nepal have risen from 51% in 2010 to 60% in 2014. This study assessed the distribution and determinants of NCD risk factors among the Nepalese adult population.
A nationally representative cross-sectional survey was conducted from Jan to June 2013 on the prevalence of NCD risk factors using the WHO NCD STEPS instrument. A multistage cluster sampling method was used to randomly select the 4,200 respondents. The adjusted prevalence ratio (APR) was used to assess the determinants of NCD risk factors using a Poisson regression model. The prevalence of current smoking (last 30 days) was 19% (95%CI:16.6-20.6), and harmful alcohol consumption (≥60 g of pure alcohol for men and ≥40 g of pure alcohol for women on an average day) was 2% (95%CI:1.4-2.9). Almost all (99%, 95%CI:98.3-99.3) of the respondents consumed less than five servings of fruits and vegetables combined on an average day and 3% (95%CI:2.7-4.3) had low physical activity. Around 21% (95%CI:19.3-23.7) were overweight or obese (BMI≥25). The prevalence of raised blood pressure (SBP≥140 mm of Hg or DBP≥90 mm of Hg) and raised blood glucose (fasting blood glucose ≥126 mg/dl), including those on medication were 26% (95%CI:23.6-28.0) and 4% (95%CI:2.9-4.5) respectively. Almost one quarter of respondents, 23% (95%CI:20.5-24.9), had raised total cholesterol (total cholesterol ≥190 mg/dl or under current medication for raised cholesterol). he study revealed a lower prevalence of smoking among women than men (APR:0.30; 95%CI:0.25-0.36), and in those who had higher education levels compared to those with no formal education (APR:0.39; 95%CI:0.26-0.58). Harmful alcohol use was also lower in women than men (APR:0.26; 95%CI:0.14-0.48), and in Terai residents compared to hill residents (APR:0.16; 95%CI:0.07-0.36). Physical inactivity was lower among women than men (APR:0.55; 95%CI:0.38-0.80), however women were significantly more overweight and obese (APR:1.19; 95%CI:1.02-1.39). Being overweight or obese was significantly less prevalent in mountain residents than in hill residents (APR:0.41; 95%CI:0.21-0.80), and in rural compared to urban residents (APR:1.39; 95%CI:1.15-1.67). Lower prevalence of raised blood pressure was observed among women than men (APR:0.69; 95%CI: 0.60-0.80). Higher prevalence of raised blood glucose was observed among urban residents compared to rural residents (APR:2.05; 95%CI:1.29-3.25). A higher prevalence of raised total cholesterol was observed among the respondents having higher education levels compared to those respondents having no formal education (APR:1.76; 95%CI:1.35-2.28).
The prevalence of low fruit and vegetable consumption, overweight and obesity, raised blood pressure and raised total cholesterol is markedly high among the Nepalese population, with variation by demographic and ecological factors and urbanization. Prevention, treatment and control of NCDs and their risk factors in Nepal is an emerging public health problem in the country, and targeted interventions with a multi-sectoral approach need to be urgently implemented.
世界卫生组织(WHO)估计,尼泊尔非传染性疾病(NCDs)导致的死亡人数占比已从2010年的51%升至2014年的60%。本研究评估了尼泊尔成年人群中非传染性疾病风险因素的分布及决定因素。
2013年1月至6月,采用WHO非传染性疾病监测工具(NCD STEPS)对非传染性疾病风险因素的患病率开展了一项具有全国代表性的横断面调查。采用多阶段整群抽样方法随机选取了4200名受访者。使用泊松回归模型,通过调整患病率比(APR)评估非传染性疾病风险因素的决定因素。当前吸烟率(过去30天内)为19%(95%CI:16.6 - 20.6),有害饮酒率(男性平均每日纯酒精摄入量≥60克,女性≥40克)为2%(95%CI:1.4 - 2.9)。几乎所有受访者(99%,95%CI:98.3 - 99.3)平均每日摄入的水果和蔬菜总量不足五份,3%(95%CI:2.7 - 4.3)的人身体活动不足。约21%(95%CI:19.3 - 23.7)的人体重超重或肥胖(BMI≥25)。血压升高(收缩压≥140 mmHg或舒张压≥90 mmHg)和血糖升高(空腹血糖≥126 mg/dl)的患病率,包括正在接受治疗的患者,分别为26%(95%CI:23.6 - 28.0)和4%(95%CI:2.9 - 4.5)。近四分之一的受访者,即23%(95%CI:20.5 - 24.9),总胆固醇升高(总胆固醇≥190 mg/dl或正在接受降胆固醇治疗)。研究显示,女性吸烟率低于男性(APR:0.30;95%CI:0.25 - 0.36),与未接受正规教育的人相比,受过高等教育的人吸烟率更低(APR:0.39;95%CI:0.26 - 0.58)。女性有害饮酒率也低于男性(APR:0.26;95%CI:0.14 - 0.48),与山区居民相比,特莱地区居民的有害饮酒率更低(APR:0.16;95%CI:0.07 - 0.36)。女性身体活动不足的比例低于男性(APR:0.55;95%CI:0.38 - 0.80),然而女性超重和肥胖的比例显著更高(APR:1.19;95%CI:1.02 - 1.39)。山区居民超重或肥胖的患病率显著低于山区居民(APR:0.41;95%CI:0.21 - 0.80),农村居民低于城市居民(APR:1.39;95%CI:1.15 - 1.67)。女性血压升高的患病率低于男性(APR:0.69;95%CI:0.60 - 0.80)。与农村居民相比,城市居民血糖升高的患病率更高(APR:2.05;95%CI:1.29 - 3.25)。与未接受正规教育的受访者相比,受过高等教育的受访者总胆固醇升高的患病率更高(APR:1.76;95%CI:1.35 - 2.28)。
尼泊尔人群中水果和蔬菜摄入量低、超重和肥胖、血压升高及总胆固醇升高的患病率显著较高,且因人口统计学、生态因素及城市化程度存在差异。在尼泊尔,预防、治疗和控制非传染性疾病及其风险因素是一个新出现的公共卫生问题,亟需采取多部门针对性干预措施。