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尼泊尔城市人口中与非传染性疾病相关的社会决定因素和风险因素:利用STEPS调查对城市贫困人口、中等收入人群和富裕人群进行的比较研究。

Social determinants and risk factors associated with non-communicable diseases among urban population in Nepal: A comparative study of poor, middle and rich wealth categories of urban population using STEPS survey.

作者信息

Kakchapati Sampurna, Neupane Raju, Baral Kriti Sagar, Shrestha Grishu, Joshi Deepak, Dawkins Bryony, Ensor Tim, Elsey Helen, Baral Sushil Chandra

机构信息

HERD International, Lalitpur, Nepal.

Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom.

出版信息

PLoS One. 2025 May 14;20(5):e0307622. doi: 10.1371/journal.pone.0307622. eCollection 2025.

Abstract

BACKGROUND

Non-communicable diseases (NCDs) are significant public health concern globally, and the burden is disproportionately high among urban populations. This study aims to compare the social determinants, NCD risk, and NCD prevalence among different wealth categories and to determine the factors associated with hypertension, obesity, and diabetes among the urban population of Nepal.

METHODS

This study used urban population data from cross-sectional STEP wise approach to NCD risk factor surveillance (STEPS) survey of 2019, resulting in a sample of 3460 individuals of 15-69 years for inclusion in the analysis. We used bivariate analysis to compare the social determinants, NCD risk and NCD prevalence among urban poor, urban middle and urban rich and multivariate logistic regression to determine the association between social determinants, NCD risks and obesity, hypertension and diabetes among urban population.

RESULTS

The study found significant differences in hypertension, obesity and diabetes by gender, ethnicity, education, employment, smoking habits, and cholesterol levels between the three wealth groups. Among the urban poor, low education, unemployment and smoking habits were more prevalent, while high cholesterol was more prevalent among the urban rich. The significant factors associated with overweight and obesity after Bonferroni correction included Hilly region with higher odds of overweight (AOR=2.33, 95% CI=1.45-3.75,). In contrast, being from Karnali (AOR= 0.36, 95% CI=0.22-0.58) and Sudurpaschim (AOR=0.42, 95% CI=0.26-0.66) provinces were associated with lower odds of overweight and cholesterol, while cholesterol was associated with higher odds of obesity (AOR=1.01, 95% CI=1.01-1.02). Disadvantaged janajatis had the lower odds of overweight (AOR = 0.52, 95% CI = 0.36-0.78). Factors that remained significantly associated with hypertension and pre-hypertension after Bonferroni correction included: age, with higher odds of hypertension (AOR=1.03, 95% CI=1.02-1.04); men, who had higher odds of both pre-hypertension (AOR=1.68, 95% CI=1.19-2.36) and hypertension (AOR=2.23, 95% CI=1.56-3.47). Being obese (AOR = 5.12, 95% CI = 2.95-8.87, p = 0.001) and overweight (AOR = 1.69, 95% CI = 1.19-2.39, p = 0.003) were significantly associated with hypertension. Similarly, urban population residing in the hilly region had higher odds of diabetes (AOR=6.44, 95% CI=3.31-11.10) compared to the mountain region; those living in the Tarai region had higher odds of pre-diabetes (AOR=5.07, 95% CI=2.44-10.5) and diabetes (AOR=5.96, 95% CI=3.12-19.86). Respondents with high cholesterol higher odds of both pre-hypertension (AOR=1.00, 95% CI=1.00-1.02) and hypertension (AOR=1.03, 95% CI=1.02-1.04), pre-diabetics (AOR=1.00, 95% CI=1.00-1.02) and diabetics (AOR=1.03, 95% CI=1.02-1.04).

CONCLUSION

The findings indicate significant disparities in education, employment, and lifestyle habits across wealth groups; urban poor lacked education and employment. Factors such as ecological region, province, gender and age were associated with an increased risk of various health conditions such as being overweight, pre-hypertension, pre-diabetes, and diabetes. Improved health outcomes among urban populations interventions targeting increased access to education, additional investment in specific areas where outcomes are worst, and interventions to improve equitable access to healthcare are needed.

摘要

背景

非传染性疾病是全球重大的公共卫生问题,城市人口中的负担尤为沉重。本研究旨在比较不同财富类别之间的社会决定因素、非传染性疾病风险和非传染性疾病患病率,并确定尼泊尔城市人口中与高血压、肥胖症和糖尿病相关的因素。

方法

本研究使用了2019年非传染性疾病风险因素监测(STEPS)横断面调查的城市人口数据,最终纳入分析的样本为3460名15至69岁的个体。我们使用双变量分析来比较城市贫困人口、城市中等收入人群和城市富裕人群之间的社会决定因素、非传染性疾病风险和非传染性疾病患病率,并使用多变量逻辑回归来确定城市人口中社会决定因素、非传染性疾病风险与肥胖症、高血压和糖尿病之间的关联。

结果

研究发现,三个财富群体在高血压、肥胖症和糖尿病方面,在性别、种族、教育程度、就业情况、吸烟习惯和胆固醇水平上存在显著差异。在城市贫困人口中,低教育程度、失业和吸烟习惯更为普遍,而高胆固醇在城市富裕人群中更为普遍。经Bonferroni校正后,与超重和肥胖相关的显著因素包括:居住在丘陵地区的人群超重几率更高(调整后比值比[AOR]=2.33,95%置信区间[CI]=1.45-3.75)。相比之下,来自卡纳利省(AOR=0.36,95%CI=0.22-0.58)和苏都尔帕希姆省(AOR=0.42,95%CI=0.26-0.66)的人群超重和胆固醇水平较低的几率较高,而胆固醇与肥胖几率较高相关(AOR=1.01,95%CI=1.01-1.02)。处于劣势的贾纳贾蒂族超重几率较低(AOR = 0.52,95%CI = 0.36-0.78)。经Bonferroni校正后,与高血压和高血压前期仍显著相关的因素包括:年龄,高血压几率较高(AOR=1.03,95%CI=1.02-1.04);男性,高血压前期(AOR=1.68,95%CI=1.19-2.36)和高血压(AOR=2.23,95%CI=1.56-3.47)的几率均较高。肥胖(AOR = 5.12,95%CI = 2.95-8.87,p = 0.001)和超重(AOR = 1.69,95%CI = 1.19-2.39,p = 0.003)与高血压显著相关。同样,与山区相比,居住在丘陵地区的城市人口患糖尿病的几率更高(AOR=6.44,95%CI=3.31-11.10);居住在特莱地区的人群患糖尿病前期(AOR=5.07,95%CI=2.44-10.5)和糖尿病(AOR=5.96,95%CI=3.12-19.86)的几率更高。胆固醇水平高的受访者患高血压前期(AOR=1.00,95%CI=1.00-1.02)和高血压(AOR=1.03,95%CI=1.02-1.04)、糖尿病前期(AOR=1.00,95%CI=1.00-1.02)和糖尿病(AOR=1.03,95%CI=1.02-1.04)的几率更高。

结论

研究结果表明,不同财富群体在教育、就业和生活方式习惯方面存在显著差异;城市贫困人口缺乏教育和就业机会。生态区域、省份、性别和年龄等因素与超重、高血压前期、糖尿病前期和糖尿病等各种健康状况的风险增加相关。需要通过增加教育机会、在结果最差的特定领域进行额外投资以及改善公平获得医疗保健的干预措施,来改善城市人口的健康状况。

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