Trammell Samuel A J, Brenner Charles
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Obesity Research & Education Initiative, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Cell Metab. 2015 Aug 4;22(2):200-1. doi: 10.1016/j.cmet.2015.07.017.
High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.
NNMT是一种将烟酰胺转化为1-甲基烟酰胺的酶,其在脂肪组织中的高表达与肥胖相关。虽然在脂肪和肝脏中敲除小鼠的NNMT可防止高脂饮食导致体重增加,但Hong等人(2015年)现在表明,NNMT在肝脏中的高表达可通过稳定SIRT1来改善脂质参数。