烟酰胺N-甲基转移酶：不仅仅是一种维生素B3清除酶。
Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme.
作者信息
Pissios Pavlos
机构信息
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
出版信息
Trends Endocrinol Metab. 2017 May;28(5):340-353. doi: 10.1016/j.tem.2017.02.004. Epub 2017 Mar 11.
Abstract
Nicotinamide (NAM) N-methyltransferase (NNMT) was originally identified as the enzyme responsible for the methylation of NAM, one of the forms of vitamin B3. Methylated NAM is eventually excreted from the body. Recent evidence has expanded the role of NNMT beyond clearance of excess vitamin B3. NNMT has been implicated in the regulation of multiple metabolic pathways in tissues such as adipose and liver as well as cancer cells through the consumption of methyl donors and generation of active metabolites. This review examines recent findings regarding the function of NNMT in physiology and disease and highlights potential new avenues for therapeutic intervention. Finally, key gaps in our knowledge about this enzymatic system and future areas of investigation are discussed.
摘要
烟酰胺（NAM）N-甲基转移酶（NNMT）最初被鉴定为负责维生素B3的一种形式——NAM甲基化的酶。甲基化的NAM最终会从体内排出。最近的证据表明，NNMT的作用已超出清除过量维生素B3的范畴。通过消耗甲基供体和产生活性代谢物，NNMT参与了脂肪和肝脏等组织以及癌细胞中多种代谢途径的调节。本综述探讨了关于NNMT在生理和疾病中的功能的最新发现，并强调了潜在的治疗干预新途径。最后，讨论了我们在这个酶系统知识方面的关键空白以及未来的研究领域。
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