双催化硝基炔与吲哚的氧化环化反应：手性季碳中心吲哚啉-3-酮的对映选择性构建。
Dual catalysis for the redox annulation of nitroalkynes with indoles: enantioselective construction of indolin-3-ones bearing quaternary stereocenters.
机构信息
College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014 (China).
出版信息
Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11205-8. doi: 10.1002/anie.201504697. Epub 2015 Aug 5.
PMID:26245887
Abstract
The enantioselective redox annulation of nitroalkynes with indoles is enabled by gold/chiral phosphoric acid dual catalysis. A range of indolin-3-one derivatives bearing quaternary stereocenters at the C2 position were afforded in good yields and excellent enantioselectivities (up to 96 % ee) from readily available starting materials.
摘要
金/手性磷酸双催化实现了硝基炔与吲哚的对映选择性氧化环化反应。一系列在 C2 位具有季立体中心的吲哚啉-3-酮衍生物可从易得的起始原料以高收率和优异的对映选择性（高达 96%ee）获得。
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