Malunga G, Mujaji W B, Musarurwa C, Nyamayaro T
Wilkins Infectious Diseases Hospital Laboratory, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Cent Afr J Med. 2012 May-Aug;58(5-6):22-5.
To evaluate the effect of Stalanev (Stavudine, Lamivudine and Nevirapine) treatment on plasma lactate levels in adults attending Beatrice Road Infectious Diseases Hospital and Wilkins Infectious Diseases Hospital Opportunistic Infections Clinics in Harare.
Prospective cohort study carried out between January and May 2011.
Beatrice Road and Wilkins Infectious Diseases Hospital Opportunistic Infections Clinics in Harare, Zimbabwe.
A convenience sample of 180 ART naive HIV infected adults aged 20-68 years who were about to be initiated on STALANEV were recruited.
The mean plasma lactate at baseline was 1.57 mmol/L (SD 0.43). After two months on STALANEV, 25 participants (13.9%) had hyperlactatemia and the mean plasma lactate level was 1.99 mmol/L (SD 0.49). At four months follow up, 98 participants (54%) had hyperlactatemia and the mean plasma lactate level was 2.65 mmol/l (SD 0.55). Mean plasma lactate levels increased significantly from baseline to 2 months follow up and from 2 months follow up to 4 months follow up (p < 0.001). None of the participants developed lactic acidosis (plasma lactate > 3.5) after two months of follow up but 14 (7.8%) developed mild lactic acidosis and three (1.7%) had moderate lactic acidosis after four months on STALANEV.
Our findings are in agreement with those of other studies that reported that treatment with STALANEV leads to hyperlactatemia thereby posing a risk for the development of lactic acidosis in patients. In the absence of alternative regimens, we recommend routine monitoring of plasma lactate levels on all patients on STALANEV in Zimbabwe.
评估司他宁（司他夫定、拉米夫定和奈韦拉平）治疗对哈拉雷比阿特丽斯路传染病医院和威尔金斯传染病医院机会性感染门诊就诊的成年患者血浆乳酸水平的影响。
2011年1月至5月进行的前瞻性队列研究。
津巴布韦哈拉雷的比阿特丽斯路和威尔金斯传染病医院机会性感染门诊。
招募了180名年龄在20 - 68岁、即将开始接受司他宁治疗的初治HIV感染成年患者，作为方便样本。
基线时血浆乳酸平均水平为1.57 mmol/L（标准差0.43）。接受司他宁治疗两个月后，25名参与者（13.9%）出现高乳酸血症，血浆乳酸平均水平为1.99 mmol/L（标准差0.49）。在四个月的随访中，98名参与者（54%）出现高乳酸血症，血浆乳酸平均水平为2.
