Bouwman Britta A M, de Laat Wouter
Hubrecht Institute - KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
Genome Biol. 2015 Aug 10;16(1):154. doi: 10.1186/s13059-015-0730-1.
The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.
基因组架构的层次水平通过调节基因和调控元件的可及性与接近程度来施加转录控制。在此，我们综述了目前对于使基因组能够灵活采用不同功能相关构象的反式作用因子的见解。
