Kurin Michael, Wiesen Jonathan, Mehta Atul C
Department of Internal Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.
Department of Pulmonary and Critical Care, Cleveland Clinic Foundation, Cleveland, OH, USA.
Clin Respir J. 2017 Jul;11(4):405-410. doi: 10.1111/crj.12354. Epub 2015 Sep 24.
Yellow nail syndrome is a rare disorder involving characteristic nail changes, lymphedema and chronic respiratory symptoms. Currently there is no definitive treatment and there have been no prospective randomised controlled trials evaluating the available options. In order to strengthen the literature on this topic, we present the case of a 67-year-old man with YNS and a detailed review of current treatment options.
We included 40 articles for the final review according to their relevance with the subject.
Data for use of the commonly chosen therapies for YNS remains inconclusive, with small studies and case reports showing mixed results of efficacy.
Although the date indicates that it is reasonable to recommend a trial of conservative therapy including vitamin E, antibiotics and compression stockings before pursuing more aggressive or invasive modalities, larger scale studies are required to determine the true efficacy of all treatment options.
黄甲综合征是一种罕见的疾病，其特征包括指甲改变、淋巴水肿和慢性呼吸道症状。目前尚无确切的治疗方法，也没有前瞻性随机对照试验来评估现有的治疗方案。为了充实关于该主题的文献，我们报告了一例67岁黄甲综合征男性患者的病例，并对当前的治疗方案进行了详细综述。
根据与主题的相关性，我们纳入了40篇文章进行最终综述。
关于黄甲综合征常用治疗方法的数据尚无定论，小型研究和病例报告显示疗效不一。
尽管现有数据表明，在采用更积极或侵入性治疗方法之前，推荐试用包括维生素E、抗生素和弹力袜在内的保守治疗是合理的，但仍需要更大规模的研究来确定所有治疗方案的真正疗效。
