Yoshimoto K, Saima S, Nakamura Y, Ishikawa H, Kinoshita M, Yokohari R, Shibata S
Nihon Jinzo Gakkai Shi. 1989 Nov;31(11):1211-6.
A 28 year-old female patient who has been diagnosed as having systemic lupus erythematosus (SLE) developed an acute dissecting aneurysm of the aorta (DeBakey type I). The long-term, large dose corticosteroid therapy (i.e., accumulative dose of about 60 g) administered for the treatment of lupus nephritis (WHO class III----IV) was considered to be responsible for a hypercholesterolemia (300-560 mg/dl) and a steroid-dependent hypertension (WHO class III) in this patient. The autopsy findings for the aorta were compatible with atherosclerotic changes but not with lupus arteritis. While atherosclerotic cardiovascular complications have been considered to be rare in patients with SLE, a growing body of evidence suggests that the incidence of such a complication may be increasing along with a dramatic improvement in the longevity of patients with SLE after an introduction of a large dose, long-term corticosteroid therapy.
一名28岁的女性患者，已被诊断患有系统性红斑狼疮（SLE），发生了主动脉急性夹层动脉瘤（DeBakey I型）。该患者因狼疮性肾炎（WHO III - IV级）接受长期大剂量皮质类固醇治疗（即累积剂量约60g），被认为是导致其高胆固醇血症（300 - 560mg/dl）和类固醇依赖性高血压（WHO III级）的原因。主动脉的尸检结果与动脉粥样硬化改变相符，但与狼疮性动脉炎不符。虽然动脉粥样硬化性心血管并发症在SLE患者中被认为很少见，但越来越多的证据表明，随着大剂量长期皮质类固醇治疗的引入，SLE患者寿命显著延长，这种并发症的发生率可能正在增加。
