Rh(I)催化甲基取代的丙二烯与炔烃发生[2 + 2 + 1]环加成反应的条件。
Conditions for a Rh(I)-catalyzed [2 + 2 + 1] cycloaddition reaction with methyl substituted allenes and alkynes.
作者信息
Wells Sarah M, Brummond Kay M
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
出版信息
Tetrahedron Lett. 2015 Jun 3;56(23):3546-3549. doi: 10.1016/j.tetlet.2015.01.075.
Abstract
The direct installation of the C4 and C10 methyl groups present in the 6,12-guaianolide framework using a Rh(I)-catalyzed cyclocarbonylation reaction of methyl subsituted allenes and alkynes is described. High yields of bicyclo[5.3.0]decanes are afforded when low reaction concentrations involving syringe pump addition of the allene-yne to the catalyst are used.
摘要
描述了使用铑（I）催化的甲基取代丙二烯和炔烃的环羰基化反应直接安装6,12-愈创木烷内酯骨架中存在的C4和C10甲基。当使用涉及通过注射泵将丙二烯-炔烃添加到催化剂的低反应浓度时，可获得高产率的双环[5.3.0]癸烷。
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