Wu Ming-Kung, Huang Tiao-Lai, Huang Kai-Wei, Huang Ya-Ling, Hung Yi-Yung
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan ; Genomic and Proteomic Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Neuropsychiatr Dis Treat. 2015 Jul 30;11:1853-7. doi: 10.2147/NDT.S88430. eCollection 2015.
In our previous study, toll-like receptor 4 (TLR4) mRNA expression level was associated with severity of major depressive disorder (MDD) evaluated with the 17-item Hamilton Depression Rating Scale (HAMD-17). However, there are few studies that have investigated the relationship between symptoms of MDD and changes in TLR4 expression. Therefore, the aim of the present study was to further analyze the association between subscales of HAMD-17 and TLR4.
Fifty-one patients with MDD (15 male and 36 female) participated in this study. HAMD-17 was used to assess the symptoms of major depression. The mRNA expression levels of TLR4 were examined in parallel with a housekeeping gene, using real-time polymerase chain reaction. A stepwise linear regression forward model was used to evaluate the relationships between items of HAMD-17 and TLR4 expression.
Some sickness behavior-associated symptoms, including suicide, somatic symptoms of anxiety, or performance of work and activities, were not associated with TLR4 expression. However, psychological signs of anxiety and loss of weight in HAMD-17 can predict the expression level of TLR4.
Our results suggest a significant association between anxiety, body weight loss, and TLR4 mRNA levels in patients with MDD. Larger longitudinal studies combining both subjective and objective measures of depression are needed to clarify the link between TLR4 and symptoms of depression.
在我们之前的研究中，Toll样受体4（TLR4）mRNA表达水平与用17项汉密尔顿抑郁量表（HAMD - 17）评估的重度抑郁症（MDD）严重程度相关。然而，很少有研究调查MDD症状与TLR4表达变化之间的关系。因此，本研究的目的是进一步分析HAMD - 17各分量表与TLR4之间的关联。
51例MDD患者（15例男性，36例女性）参与了本研究。使用HAMD - 17评估重度抑郁症状。采用实时聚合酶链反应，将TLR4的mRNA表达水平与一个管家基因平行检测。采用逐步线性回归向前模型评估HAMD - 17各项与TLR4表达之间的关系。
一些与疾病行为相关的症状，包括自杀、焦虑的躯体症状或工作及活动表现，与TLR4表达无关。然而，HAMD - 17中的焦虑心理症状和体重减轻可以预测TLR4的表达水平。
我们的结果表明，MDD患者的焦虑、体重减轻与TLR4 mRNA水平之间存在显著关联。需要进行更大规模的纵向研究，结合抑郁的主观和客观测量方法，以阐明TLR4与抑郁症状之间的联系。
