Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University , Raleigh, North Carolina 27695, United States.
Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
ACS Nano. 2015 Sep 22;9(9):9407-15. doi: 10.1021/acsnano.5b03975. Epub 2015 Aug 10.
Mechanical force-based stimulus provides a simple and easily accessible manner for spatiotemporally controlled drug delivery. Here we describe a wearable, tensile strain-triggered drug delivery device consisting of a stretchable elastomer and microgel depots containing drug loaded nanoparticles. By applying a tensile strain to the elastomer film, the release of drug from the microdepot is promoted due to the enlarged surface area for diffusion and Poisson's ratio-induced compression on the microdepot. Correspondingly, both sustained drug release by daily body motions and pulsatile release by intentional administration can be conveniently achieved. Our work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments. Moreover, polymeric microneedles were further integrated with the stretch-responsive device for transcutaneous delivery of insulin and regulation of blood glucose levels of chemically induced type 1 diabetic mice.
基于机械力的刺激为药物的时空控制释放提供了一种简单、便捷的方法。在这里，我们描述了一种可穿戴的、拉伸应变触发的药物输送装置，它由可拉伸弹性体和含有载药纳米颗粒的微凝胶库组成。通过对弹性体薄膜施加拉伸应变，由于扩散的表面积增大和泊松比引起的微库压缩，促进了药物从微库中的释放。相应地，日常身体运动的持续药物释放和有意管理的脉冲释放都可以方便地实现。我们的工作表明，施加于可拉伸装置的拉伸应变促进了微库中治疗药物的释放，可用于癌症和细菌感染的治疗。此外，聚合物微针进一步与对拉伸响应的装置集成，用于经皮输送胰岛素和调节化学诱导的 1 型糖尿病小鼠的血糖水平。
