Lee Hyeokjun, Song Soojeong, Yea Junwoo, Ha Jeongdae, Oh Saehyuck, Jekal Janghwan, Hong Myung Seok, Won Chihyeong, Jung Han Hee, Keum Hohyun, Han Sangyoon, Cho Jeong Ho, Lee Taeyoon, Jang Kyung-In
Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
ASML Korea, Hwaseong, Republic of Korea.
Nat Commun. 2025 Jan 14;16(1):650. doi: 10.1038/s41467-025-55951-6.
System-level wearable electronics require to be flexible to ensure conformal contact with the skin, but they also need to integrate rigid and bulky functional components to achieve system-level functionality. As one of integration methods, folding integration offers simplified processing and enhanced functionality through rigid-soft region separation, but so far, it has mainly been applied to modality of electrical sensing and stimulation. This paper introduces a vialess heterogeneous skin patch with multi modalities that separates the soft region and strain-robust region through folded structure. Our system includes electrical and optical modalities for hemodynamic and cardiovascular monitoring, and a force-electrically driven micropump for drug delivery. Each modality is demonstrated through on-demand drug delivery, flexible waveguide-based PPG monitoring, and ECG and body movement monitoring. Wireless data transmission and real-time measurement validate the feedback operation for multi-modalities. This engineered closed-loop platform offers the possibility for broad applications, including cardiovascular monitoring and chronic disease management.
系统级可穿戴电子产品需要具备灵活性，以确保与皮肤紧密贴合，但它们还需要集成刚性且体积较大的功能组件，以实现系统级功能。作为一种集成方法，折叠集成通过软硬区域分离提供了简化的处理过程并增强了功能，但到目前为止，它主要应用于电传感和刺激模式。本文介绍了一种无瓶异构皮肤贴片，它通过折叠结构将柔软区域和应变稳健区域分开，具有多种模式。我们的系统包括用于血液动力学和心血管监测的电学和光学模式，以及用于药物输送的力电驱动微型泵。每种模式都通过按需药物输送、基于柔性波导的PPG监测以及心电图和身体运动监测得到了验证。无线数据传输和实时测量验证了多模式的反馈操作。这个经过设计的闭环平台为广泛的应用提供了可能性，包括心血管监测和慢性病管理。
