Shvets V N, Pankova A S, Go'ldovskaia M D, Vnukova Z E
Kosm Biol Aviakosm Med. 1989 Nov-Dec;23(6):39-42.
During 35-day hypokinesia rat spongy bone in the tibia and vertebrae varied in two phases. The first phase (up to 15 days) was induced by a stress-reaction and the second phase by adaptation to hypokinesia. Under the influence of subcutaneous injections of hydroxydimethyl aminopropylidene biphosphonate (AMOK) at a dose of 0.01 mg/kg/day bone changes disappeared: throughout the study spongy bone mass remained as in controls. AMOK administration at a dose of 5 mg/kg/day 10 days prior to hypokinetic exposure did not eliminate its inhibitory effect although the initial bone mass was 1.5-2 times higher than in the controls. However at the adaptation phase (beginning with day 15) bone mass increased, reaching the baseline. This indicates a decline in bone sensitivity to muscle unloading. It is concluded that AMOK modifies bone responses to various hypokinetic factors.
在35天的低动力状态下，大鼠胫骨和椎骨的松质骨变化分为两个阶段。第一阶段（长达15天）由应激反应引起，第二阶段由对低动力状态的适应引起。皮下注射剂量为0.01毫克/千克/天的羟二甲基氨丙基亚甲基二膦酸盐（AMOK）后，骨骼变化消失：在整个研究过程中，松质骨质量保持与对照组相同。在低动力暴露前10天以5毫克/千克/天的剂量给予AMOK，尽管初始骨质量比对照组高1.5至2倍，但并未消除其抑制作用。然而，在适应阶段（从第15天开始），骨质量增加，达到基线水平。这表明骨骼对肌肉卸载的敏感性下降。得出的结论是，AMOK改变了骨骼对各种低动力因素的反应。
